HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma

HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma

Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer that is challenging to diagnose at an early stage. Despite recent advances in combination chemotherapy, drug resistance limits the therapeutic value of this regimen. iCCA reportedly harbors high HMGA1 expression...

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Bibliographic Details
Main Authors: Zhipeng Li, Huaxin Zhou, Zhijia Xia, Tong Xia, Gang Du, Strohmer Dorothee Franziska, Xiaoming Li, Xiangyu Zhai, Bin Jin
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Biomarker Research
Subjects:
Intrahepatic cholangiocarcinoma (iCCA)
HMGA1
PI3K/mTOR
CDK4/6
Palbociclib
PF-04691502
Online Access:https://doi.org/10.1186/s40364-023-00473-w

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