Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases
Brain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities. The delicate nature of the brain further complicates the decision of eliminating as much tumorous tissue as possible wh...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/11/8/376 |
| _version_ | 1828115657496985600 |
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| author | Janik Puttemans Tony Lahoutte Matthias D’Huyvetter Nick Devoogdt |
| author_facet | Janik Puttemans Tony Lahoutte Matthias D’Huyvetter Nick Devoogdt |
| author_sort | Janik Puttemans |
| collection | DOAJ |
| description | Brain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities. The delicate nature of the brain further complicates the decision of eliminating as much tumorous tissue as possible while protecting healthy tissue. Despite recent advances in immunotherapy, radiotherapy and systemic treatments, prognosis of newly diagnosed patients remains dismal, and recurrence is still a universal problem. Several strategies are now under preclinical and clinical investigation to optimize delivery and maximize the cytotoxic potential of pharmaceuticals with regards to brain tumors. This review provides an overview of targeted radionuclide therapy approaches for the treatment of primary brain tumors and brain metastases, with an emphasis on biological targeting moieties that specifically target key biomarkers involved in cancer development. |
| first_indexed | 2024-04-11T12:43:53Z |
| format | Article |
| id | doaj.art-134366968bd6496798335fe35d50ce7b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T12:43:53Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-134366968bd6496798335fe35d50ce7b2022-12-22T04:23:24ZengMDPI AGPharmaceutics1999-49232019-08-0111837610.3390/pharmaceutics11080376pharmaceutics11080376Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and MetastasesJanik Puttemans0Tony Lahoutte1Matthias D’Huyvetter2Nick Devoogdt3In Vivo Cellular and Molecular Imaging Lab, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumIn Vivo Cellular and Molecular Imaging Lab, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumIn Vivo Cellular and Molecular Imaging Lab, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumIn Vivo Cellular and Molecular Imaging Lab, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumBrain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities. The delicate nature of the brain further complicates the decision of eliminating as much tumorous tissue as possible while protecting healthy tissue. Despite recent advances in immunotherapy, radiotherapy and systemic treatments, prognosis of newly diagnosed patients remains dismal, and recurrence is still a universal problem. Several strategies are now under preclinical and clinical investigation to optimize delivery and maximize the cytotoxic potential of pharmaceuticals with regards to brain tumors. This review provides an overview of targeted radionuclide therapy approaches for the treatment of primary brain tumors and brain metastases, with an emphasis on biological targeting moieties that specifically target key biomarkers involved in cancer development.https://www.mdpi.com/1999-4923/11/8/376brain cancerbrain metastasisradionuclide therapy |
| spellingShingle | Janik Puttemans Tony Lahoutte Matthias D’Huyvetter Nick Devoogdt Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases Pharmaceutics brain cancer brain metastasis radionuclide therapy |
| title | Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases |
| title_full | Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases |
| title_fullStr | Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases |
| title_full_unstemmed | Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases |
| title_short | Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases |
| title_sort | beyond the barrier targeted radionuclide therapy in brain tumors and metastases |
| topic | brain cancer brain metastasis radionuclide therapy |
| url | https://www.mdpi.com/1999-4923/11/8/376 |
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