Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study
Background: Benign paroxysmal positional vertigo (BPPV) is linked to vitamin D deficiency. This clinical trial aimed to determine the influence of vitamin D supplementation on intensity of BPPV. Methods: The study population was selected consecutively and the diagnosis of BPPV was made by history a...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2016-04-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/browse.php?a_code=A-10-263-4&slc_lang=en&sid=1 |
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| author | Mahboobeh Sheikhzadeh Yones Lotfi Abdollah Mousavi Behzad Heidari Mohsen Monadi Enayatollah Bakhshi |
| author_facet | Mahboobeh Sheikhzadeh Yones Lotfi Abdollah Mousavi Behzad Heidari Mohsen Monadi Enayatollah Bakhshi |
| author_sort | Mahboobeh Sheikhzadeh |
| collection | DOAJ |
| description | Background: Benign paroxysmal positional vertigo (BPPV) is linked to vitamin D deficiency. This clinical trial aimed to determine the influence of vitamin D supplementation on intensity of BPPV.
Methods: The study population was selected consecutively and the diagnosis of BPPV was made by history and clinical examination and exclusion of other conditions. Intensity of BPVV was assessed based on VAS score (0-10). Serum 25-hydroxyvitamin D (25-OHD) was measured using ELISA method and levels < 20 ng/ml was considered a deficiency. All patients received rehabilitation treatment using Epley's maneuver one time per week for one month. Serum 25-OHD deficient patients were classified as treated and non-treated groups (rehabilitation with or without 50.000 IU cholecalciferol weekly for two months).The results of treatment were compared with vitamin D sufficient group as control. All patients were followed-up for 6 months.
Results: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.
Conclusion: This study indicates that correction of vitamin D deficiency in BPPV provides additional benefit to rehabilitation therapy (Epley maneuver) regarding duration of improvement. These findings suggest serum 25-OHD measurement in recurrent BPPV. |
| first_indexed | 2024-04-14T02:52:06Z |
| format | Article |
| id | doaj.art-1346c573be004f4b97382b7f09aaca8b |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-04-14T02:52:06Z |
| publishDate | 2016-04-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-1346c573be004f4b97382b7f09aaca8b2022-12-22T02:16:14ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722016-04-01729398Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical studyMahboobeh Sheikhzadeh0Yones Lotfi1Abdollah Mousavi2Behzad Heidari3Mohsen Monadi4Enayatollah Bakhshi5 University of Social Welfare and Rehabilitation Sciences, Tehran, Iran University of Social Welfare and Rehabilitation Sciences, Tehran, Iran University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Ganjafrooz Street, Babol University of Medical Science, Iran Clinical Research Development Unit of Rouhani Hospital, Master of Science of Department of Audiology, Babol University of Medical Sciences, Babol, Iran. University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Background: Benign paroxysmal positional vertigo (BPPV) is linked to vitamin D deficiency. This clinical trial aimed to determine the influence of vitamin D supplementation on intensity of BPPV. Methods: The study population was selected consecutively and the diagnosis of BPPV was made by history and clinical examination and exclusion of other conditions. Intensity of BPVV was assessed based on VAS score (0-10). Serum 25-hydroxyvitamin D (25-OHD) was measured using ELISA method and levels < 20 ng/ml was considered a deficiency. All patients received rehabilitation treatment using Epley's maneuver one time per week for one month. Serum 25-OHD deficient patients were classified as treated and non-treated groups (rehabilitation with or without 50.000 IU cholecalciferol weekly for two months).The results of treatment were compared with vitamin D sufficient group as control. All patients were followed-up for 6 months. Results: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period. Conclusion: This study indicates that correction of vitamin D deficiency in BPPV provides additional benefit to rehabilitation therapy (Epley maneuver) regarding duration of improvement. These findings suggest serum 25-OHD measurement in recurrent BPPV.http://caspjim.com/browse.php?a_code=A-10-263-4&slc_lang=en&sid=1Benign paroxysmal positional vertigo Intensity Vitamin D Rehabilitation Therapy |
| spellingShingle | Mahboobeh Sheikhzadeh Yones Lotfi Abdollah Mousavi Behzad Heidari Mohsen Monadi Enayatollah Bakhshi Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study Caspian Journal of Internal Medicine Benign paroxysmal positional vertigo Intensity Vitamin D Rehabilitation Therapy |
| title | Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study |
| title_full | Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study |
| title_fullStr | Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study |
| title_full_unstemmed | Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study |
| title_short | Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study |
| title_sort | influence of supplemental vitamin d on intensity of benign paroxysmal positional vertigo a longitudinal clinical study |
| topic | Benign paroxysmal positional vertigo Intensity Vitamin D Rehabilitation Therapy |
| url | http://caspjim.com/browse.php?a_code=A-10-263-4&slc_lang=en&sid=1 |
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