The evolving role of tiotropium in asthma
Emma R McIvor,1 R Andrew McIvor2 1Queen’s University, Belfast, UK; 2Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario, Canada Abstract: Tiotropium is a long-acting muscarinic antagonist (LAMA) that exerts its bronchodilatory effect b...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-08-01
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| Series: | Journal of Asthma and Allergy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-evolving-role-of-tiotropium-in-asthma-peer-reviewed-article-JAA |
| _version_ | 1818509391175876608 |
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| author | McIvor ER McIvor RA |
| author_facet | McIvor ER McIvor RA |
| author_sort | McIvor ER |
| collection | DOAJ |
| description | Emma R McIvor,1 R Andrew McIvor2 1Queen’s University, Belfast, UK; 2Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario, Canada Abstract: Tiotropium is a long-acting muscarinic antagonist (LAMA) that exerts its bronchodilatory effect by blocking endogenous acetylcholine receptors in the airways. Its safety and efficacy are well established for the treatment of COPD, and it is now being recognized for its role in improving lung function and control in asthma. This review discusses the evolving role of tiotropium delivered by the Respimat® in patients across the range of asthma severities and ages, and provides an overview of safety and efficacy data. Tiotropium is the only LAMA currently approved for the treatment of asthma, and evidence from a large-scale clinical trial program, including several Phase III studies in adults, has demonstrated that tiotropium improves lung function and asthma control, with a safety profile comparable with that of placebo. Clinical trials in adolescent patients (aged 12–17 years) have also shown improvements in lung function and trends toward improved asthma control. Of note, the efficacy and safety profiles are consistent regardless of baseline characteristics and phenotype. Given the large and growing body of evidence, it is likely that as clinical experience with tiotropium increases, this treatment may possibly emerge as the key choice for add-on therapy to inhaled corticosteroids/long-acting β2-agonists, and in patients who do not tolerate long-acting bronchodilators or other medications, in the future. Keywords: tiotropium, anticholinergics, asthma, efficacy |
| first_indexed | 2024-12-10T22:44:53Z |
| format | Article |
| id | doaj.art-13494e09f04f4d97874e410bcb94c6f1 |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-12-10T22:44:53Z |
| publishDate | 2017-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-13494e09f04f4d97874e410bcb94c6f12022-12-22T01:30:36ZengDove Medical PressJournal of Asthma and Allergy1178-69652017-08-01Volume1023123634231The evolving role of tiotropium in asthmaMcIvor ERMcIvor RAEmma R McIvor,1 R Andrew McIvor2 1Queen’s University, Belfast, UK; 2Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario, Canada Abstract: Tiotropium is a long-acting muscarinic antagonist (LAMA) that exerts its bronchodilatory effect by blocking endogenous acetylcholine receptors in the airways. Its safety and efficacy are well established for the treatment of COPD, and it is now being recognized for its role in improving lung function and control in asthma. This review discusses the evolving role of tiotropium delivered by the Respimat® in patients across the range of asthma severities and ages, and provides an overview of safety and efficacy data. Tiotropium is the only LAMA currently approved for the treatment of asthma, and evidence from a large-scale clinical trial program, including several Phase III studies in adults, has demonstrated that tiotropium improves lung function and asthma control, with a safety profile comparable with that of placebo. Clinical trials in adolescent patients (aged 12–17 years) have also shown improvements in lung function and trends toward improved asthma control. Of note, the efficacy and safety profiles are consistent regardless of baseline characteristics and phenotype. Given the large and growing body of evidence, it is likely that as clinical experience with tiotropium increases, this treatment may possibly emerge as the key choice for add-on therapy to inhaled corticosteroids/long-acting β2-agonists, and in patients who do not tolerate long-acting bronchodilators or other medications, in the future. Keywords: tiotropium, anticholinergics, asthma, efficacyhttps://www.dovepress.com/the-evolving-role-of-tiotropium-in-asthma-peer-reviewed-article-JAATiotropiumanticholinergicsasthmaefficacy |
| spellingShingle | McIvor ER McIvor RA The evolving role of tiotropium in asthma Journal of Asthma and Allergy Tiotropium anticholinergics asthma efficacy |
| title | The evolving role of tiotropium in asthma |
| title_full | The evolving role of tiotropium in asthma |
| title_fullStr | The evolving role of tiotropium in asthma |
| title_full_unstemmed | The evolving role of tiotropium in asthma |
| title_short | The evolving role of tiotropium in asthma |
| title_sort | evolving role of tiotropium in asthma |
| topic | Tiotropium anticholinergics asthma efficacy |
| url | https://www.dovepress.com/the-evolving-role-of-tiotropium-in-asthma-peer-reviewed-article-JAA |
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