Emerging Roles of ADAMTSs in Angiogenesis and Cancer
A Disintegrin-like And Metalloproteinase with ThromboSpondin motifs—ADAMTSs—are a multi-domain, secreted, extracellular zinc metalloproteinase family with 19 members in humans. These extracellular metalloproteinases are known to cleave a wide range of substrates in the ex...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-11-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/4/4/1252 |
| _version_ | 1797714612849737728 |
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| author | Ruowen Ge Nithya Rao Saran Kumar |
| author_facet | Ruowen Ge Nithya Rao Saran Kumar |
| author_sort | Ruowen Ge |
| collection | DOAJ |
| description | A Disintegrin-like And Metalloproteinase with ThromboSpondin motifs—ADAMTSs—are a multi-domain, secreted, extracellular zinc metalloproteinase family with 19 members in humans. These extracellular metalloproteinases are known to cleave a wide range of substrates in the extracellular matrix. They have been implicated in various physiological processes, such as extracellular matrix turnover, melanoblast development, interdigital web regression, blood coagulation, ovulation, etc. ADAMTSs are also critical in pathological processes such as arthritis, atherosclerosis, cancer, angiogenesis, wound healing, etc. In the past few years, there has been an explosion of reports concerning the role of ADAMTS family members in angiogenesis and cancer. To date, 10 out of the 19 members have been demonstrated to be involved in regulating angiogenesis and/or cancer. The mechanism involved in their regulation of angiogenesis or cancer differs among different members. Both angiogenesis-dependent and -independent regulation of cancer have been reported. This review summarizes our current understanding on the roles of ADAMTS in angiogenesis and cancer and highlights their implications in cancer therapeutic development. |
| first_indexed | 2024-03-12T07:54:31Z |
| format | Article |
| id | doaj.art-134ba02ebaa9470f869022a72638737c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:54:31Z |
| publishDate | 2012-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-134ba02ebaa9470f869022a72638737c2023-09-02T20:17:09ZengMDPI AGCancers2072-66942012-11-01441252129910.3390/cancers4041252Emerging Roles of ADAMTSs in Angiogenesis and CancerRuowen GeNithya RaoSaran KumarA Disintegrin-like And Metalloproteinase with ThromboSpondin motifs—ADAMTSs—are a multi-domain, secreted, extracellular zinc metalloproteinase family with 19 members in humans. These extracellular metalloproteinases are known to cleave a wide range of substrates in the extracellular matrix. They have been implicated in various physiological processes, such as extracellular matrix turnover, melanoblast development, interdigital web regression, blood coagulation, ovulation, etc. ADAMTSs are also critical in pathological processes such as arthritis, atherosclerosis, cancer, angiogenesis, wound healing, etc. In the past few years, there has been an explosion of reports concerning the role of ADAMTS family members in angiogenesis and cancer. To date, 10 out of the 19 members have been demonstrated to be involved in regulating angiogenesis and/or cancer. The mechanism involved in their regulation of angiogenesis or cancer differs among different members. Both angiogenesis-dependent and -independent regulation of cancer have been reported. This review summarizes our current understanding on the roles of ADAMTS in angiogenesis and cancer and highlights their implications in cancer therapeutic development.http://www.mdpi.com/2072-6694/4/4/1252angiogenesiscancerADAMTSmetalloproteinaseproteoglycanasetumorigenesismetastasis |
| spellingShingle | Ruowen Ge Nithya Rao Saran Kumar Emerging Roles of ADAMTSs in Angiogenesis and Cancer Cancers angiogenesis cancer ADAMTS metalloproteinase proteoglycanase tumorigenesis metastasis |
| title | Emerging Roles of ADAMTSs in Angiogenesis and Cancer |
| title_full | Emerging Roles of ADAMTSs in Angiogenesis and Cancer |
| title_fullStr | Emerging Roles of ADAMTSs in Angiogenesis and Cancer |
| title_full_unstemmed | Emerging Roles of ADAMTSs in Angiogenesis and Cancer |
| title_short | Emerging Roles of ADAMTSs in Angiogenesis and Cancer |
| title_sort | emerging roles of adamtss in angiogenesis and cancer |
| topic | angiogenesis cancer ADAMTS metalloproteinase proteoglycanase tumorigenesis metastasis |
| url | http://www.mdpi.com/2072-6694/4/4/1252 |
| work_keys_str_mv | AT ruowenge emergingrolesofadamtssinangiogenesisandcancer AT nithyarao emergingrolesofadamtssinangiogenesisandcancer AT sarankumar emergingrolesofadamtssinangiogenesisandcancer |