Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD
Abstract While non-alcoholic fatty liver disease (NAFLD) has been widely studied, the pathophysiology of lean NAFLD, the critical NAFLD subgroup, remains elusive. This study aimed to clarify the association between polymorphisms of GCKR, waist circumference, and the odds of lean NAFLD in the elderly...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33753-4 |
| _version_ | 1797841057365360640 |
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| author | Na Wu Jie Li Jing Zhang Fan Yuan Ning Yu Fengwei Zhang Dong Li Jianying Wang Lei Zhang Yi Shi Guang He Guang Ji Baocheng Liu |
| author_facet | Na Wu Jie Li Jing Zhang Fan Yuan Ning Yu Fengwei Zhang Dong Li Jianying Wang Lei Zhang Yi Shi Guang He Guang Ji Baocheng Liu |
| author_sort | Na Wu |
| collection | DOAJ |
| description | Abstract While non-alcoholic fatty liver disease (NAFLD) has been widely studied, the pathophysiology of lean NAFLD, the critical NAFLD subgroup, remains elusive. This study aimed to clarify the association between polymorphisms of GCKR, waist circumference, and the odds of lean NAFLD in the elderly Chinese Han population who live in the Zhangjiang community center of Shanghai, China. Three single nucleotide polymorphisms (SNPs), including rs1260326, rs780093, and rs780094, were genotyped in MassARRAY Analyzer. The association between SNPs with waist circumference in five genetic models was analyzed and rechecked by the logistic regression analysis. Mediation models were established to evaluate whether the waist circumstance can mediate the association between SNPs and lean NAFLD. In this study, the frequency of the C allele of rs1260326, rs780093, and rs780094 was significantly lower in lean NAFLD individuals than in lean non-NAFLD ones. The association between rs1260326 in GCKR and the odds of lean NAFLD was mediated via waist circumference after adjusting gender and age in the elderly Chinese Han population (β = 1.196, R2 = 0.043, p = 0.020). For the first time, this study examined the mediating effect of waist circumference on the association between rs1260326 in GCKR and the odds of lean NAFLD (β = 0.0515, 95% CI 0.0107–0.0900, p = 0.004). It may contribute to illustrating the pathogenesis of lean NAFLD and indicate that waist circumference management might improve lean NAFLD control. |
| first_indexed | 2024-04-09T16:24:49Z |
| format | Article |
| id | doaj.art-13512877a0074a84ab4a6fded796e765 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T16:24:49Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-13512877a0074a84ab4a6fded796e7652023-04-23T11:14:39ZengNature PortfolioScientific Reports2045-23222023-04-011311910.1038/s41598-023-33753-4Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLDNa Wu0Jie Li1Jing Zhang2Fan Yuan3Ning Yu4Fengwei Zhang5Dong Li6Jianying Wang7Lei Zhang8Yi Shi9Guang He10Guang Ji11Baocheng Liu12Shanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese MedicineDepartment of Biochemistry and Molecular Biology, Capital Medical UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong UniversityShanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese MedicineZhangjiang Community Health Service Center of Pudong New DistrictShanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese MedicineBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong UniversityInstitute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese MedicineAbstract While non-alcoholic fatty liver disease (NAFLD) has been widely studied, the pathophysiology of lean NAFLD, the critical NAFLD subgroup, remains elusive. This study aimed to clarify the association between polymorphisms of GCKR, waist circumference, and the odds of lean NAFLD in the elderly Chinese Han population who live in the Zhangjiang community center of Shanghai, China. Three single nucleotide polymorphisms (SNPs), including rs1260326, rs780093, and rs780094, were genotyped in MassARRAY Analyzer. The association between SNPs with waist circumference in five genetic models was analyzed and rechecked by the logistic regression analysis. Mediation models were established to evaluate whether the waist circumstance can mediate the association between SNPs and lean NAFLD. In this study, the frequency of the C allele of rs1260326, rs780093, and rs780094 was significantly lower in lean NAFLD individuals than in lean non-NAFLD ones. The association between rs1260326 in GCKR and the odds of lean NAFLD was mediated via waist circumference after adjusting gender and age in the elderly Chinese Han population (β = 1.196, R2 = 0.043, p = 0.020). For the first time, this study examined the mediating effect of waist circumference on the association between rs1260326 in GCKR and the odds of lean NAFLD (β = 0.0515, 95% CI 0.0107–0.0900, p = 0.004). It may contribute to illustrating the pathogenesis of lean NAFLD and indicate that waist circumference management might improve lean NAFLD control.https://doi.org/10.1038/s41598-023-33753-4 |
| spellingShingle | Na Wu Jie Li Jing Zhang Fan Yuan Ning Yu Fengwei Zhang Dong Li Jianying Wang Lei Zhang Yi Shi Guang He Guang Ji Baocheng Liu Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD Scientific Reports |
| title | Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD |
| title_full | Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD |
| title_fullStr | Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD |
| title_full_unstemmed | Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD |
| title_short | Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD |
| title_sort | waist circumference mediates the association between rs1260326 in gckr gene and the odds of lean nafld |
| url | https://doi.org/10.1038/s41598-023-33753-4 |
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