Health functions and related molecular mechanisms of Miconia genus: A systematic review
The Miconia genus is traditionally used in folk medicine in Brazil and other tropical American countries and is represented by 282 species in this region. It is a multifaceted genus of medicinal plants widely used to treat rheumatoid arthritis (RA), pain, inflammatory diseases, and many more therape...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023018169 |
| _version_ | 1797851759676227584 |
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| author | Sathiyabama Rajiv Gandhi Gopalsamy Rajiv Gandhi Poovathumkal James Antony Varghese Edwin Hillary Stanislaus Antony Ceasar Govindasamy Hariharan Yi Liu Ricardo Queiroz Gurgel Jullyana de Souza Siqueira Quintans Lucindo José Quintans-Júnior |
| author_facet | Sathiyabama Rajiv Gandhi Gopalsamy Rajiv Gandhi Poovathumkal James Antony Varghese Edwin Hillary Stanislaus Antony Ceasar Govindasamy Hariharan Yi Liu Ricardo Queiroz Gurgel Jullyana de Souza Siqueira Quintans Lucindo José Quintans-Júnior |
| author_sort | Sathiyabama Rajiv Gandhi |
| collection | DOAJ |
| description | The Miconia genus is traditionally used in folk medicine in Brazil and other tropical American countries and is represented by 282 species in this region. It is a multifaceted genus of medicinal plants widely used to treat rheumatoid arthritis (RA), pain, inflammatory diseases, and many more therapeutic applications. In the present study, we systematically identify and discuss the literature on in vivo and in vitro studies focusing on the therapeutic potentials and related molecular mechanisms of the Miconia genus. The review also assessed phytochemicals and their pharmacological properties and considered safety concerns related to the genus. Literature searches to identify studies on the Miconia genus were carried out through four main electronic databases, namely PubMed, Embase, Scopus, and Web of Science limited to Medical Subjects Headings (MeSH) and Descriptores en Ciencias de la Salud (DCS) (Health Sciences Descriptors) to identify studies published up to December 2022. The relevant information about the genus was gathered using the keywords ‘Miconia’, ‘biological activities’, ‘therapeutic mechanisms’, ‘animal model, ‘cell-line model’, ‘antinociceptive’, ‘hyperalgesia’, ‘anti-inflammatory’, and ‘inflammation’. The therapeutic potentials and mechanisms of action of 14 species from genus Miconia were examined in 18 in vitro studies and included their anti-inflammatory, anticancer, analgesic, antibacterial, cytotoxic, mutagenic, antioxidant, anti-leishmanial, antinociceptive, schistosomicidal, and anti-osteoarthritis potentials, and in eight in vivo studies, assessing their analgesic, antioxidant, antinociceptive, and anti-osteoarthritis activities. Some of the main related molecular mechanisms identified are the modulation of cytokines such as IL-1β, IL-6, and TNF-α, as well as the inhibition of inflammatory mediators and prostaglandin synthesis. The limited number of studies showed that commonly available species from the genus Miconia are safe for consumption. Miconia albicans Sw.Triana and Miconia rubiginosa (Bonpl.) DC was the most frequently used species and showed significant efficacy and potential for developing safe drugs to treat pain and inflammation. |
| first_indexed | 2024-04-09T19:21:56Z |
| format | Article |
| id | doaj.art-1353b00339e14bbba7b23506d81d7794 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:21:56Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1353b00339e14bbba7b23506d81d77942023-04-05T08:27:25ZengElsevierHeliyon2405-84402023-03-0193e14609Health functions and related molecular mechanisms of Miconia genus: A systematic reviewSathiyabama Rajiv Gandhi0Gopalsamy Rajiv Gandhi1Poovathumkal James Antony2Varghese Edwin Hillary3Stanislaus Antony Ceasar4Govindasamy Hariharan5Yi Liu6Ricardo Queiroz Gurgel7Jullyana de Souza Siqueira Quintans8Lucindo José Quintans-Júnior9Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology (DFS), Federal University of Sergipe, São Cristóvão, 49100000, Brazil; Postgraduate Program of Health Sciences (PPGCS), University Hospital, Federal University of Sergipe (HU-UFS), Campus Prof. João Cardoso Nascimento, Aracaju, 49060108, BrazilDepartment of Biosciences, Rajagiri College of Social Sciences, Kochi, 683104, IndiaNepal Jesuit Society, Human Resource Development and Research Centre, Kathmandu, 44600, NepalDepartment of Biosciences, Rajagiri College of Social Sciences, Kochi, 683104, IndiaDepartment of Biosciences, Rajagiri College of Social Sciences, Kochi, 683104, IndiaDepartment of Biochemistry, Srimad Andavan Arts and Science College (Autonomous) affiliated to the Bharathidasan University, Tiruchirapalli, 600005, IndiaResearch Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, 610213, ChinaPostgraduate Program of Health Sciences (PPGCS), University Hospital, Federal University of Sergipe (HU-UFS), Campus Prof. João Cardoso Nascimento, Aracaju, 49060108, BrazilLaboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology (DFS), Federal University of Sergipe, São Cristóvão, 49100000, Brazil; Postgraduate Program of Health Sciences (PPGCS), University Hospital, Federal University of Sergipe (HU-UFS), Campus Prof. João Cardoso Nascimento, Aracaju, 49060108, BrazilLaboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology (DFS), Federal University of Sergipe, São Cristóvão, 49100000, Brazil; Postgraduate Program of Health Sciences (PPGCS), University Hospital, Federal University of Sergipe (HU-UFS), Campus Prof. João Cardoso Nascimento, Aracaju, 49060108, Brazil; Corresponding author. Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Aracaju, 49100000, Sergipe, BrazilThe Miconia genus is traditionally used in folk medicine in Brazil and other tropical American countries and is represented by 282 species in this region. It is a multifaceted genus of medicinal plants widely used to treat rheumatoid arthritis (RA), pain, inflammatory diseases, and many more therapeutic applications. In the present study, we systematically identify and discuss the literature on in vivo and in vitro studies focusing on the therapeutic potentials and related molecular mechanisms of the Miconia genus. The review also assessed phytochemicals and their pharmacological properties and considered safety concerns related to the genus. Literature searches to identify studies on the Miconia genus were carried out through four main electronic databases, namely PubMed, Embase, Scopus, and Web of Science limited to Medical Subjects Headings (MeSH) and Descriptores en Ciencias de la Salud (DCS) (Health Sciences Descriptors) to identify studies published up to December 2022. The relevant information about the genus was gathered using the keywords ‘Miconia’, ‘biological activities’, ‘therapeutic mechanisms’, ‘animal model, ‘cell-line model’, ‘antinociceptive’, ‘hyperalgesia’, ‘anti-inflammatory’, and ‘inflammation’. The therapeutic potentials and mechanisms of action of 14 species from genus Miconia were examined in 18 in vitro studies and included their anti-inflammatory, anticancer, analgesic, antibacterial, cytotoxic, mutagenic, antioxidant, anti-leishmanial, antinociceptive, schistosomicidal, and anti-osteoarthritis potentials, and in eight in vivo studies, assessing their analgesic, antioxidant, antinociceptive, and anti-osteoarthritis activities. Some of the main related molecular mechanisms identified are the modulation of cytokines such as IL-1β, IL-6, and TNF-α, as well as the inhibition of inflammatory mediators and prostaglandin synthesis. The limited number of studies showed that commonly available species from the genus Miconia are safe for consumption. Miconia albicans Sw.Triana and Miconia rubiginosa (Bonpl.) DC was the most frequently used species and showed significant efficacy and potential for developing safe drugs to treat pain and inflammation.http://www.sciencedirect.com/science/article/pii/S2405844023018169MiconiaTherapeutic mechanismAnimal modelAntioxidantAnalgesicAnti-inflammatory |
| spellingShingle | Sathiyabama Rajiv Gandhi Gopalsamy Rajiv Gandhi Poovathumkal James Antony Varghese Edwin Hillary Stanislaus Antony Ceasar Govindasamy Hariharan Yi Liu Ricardo Queiroz Gurgel Jullyana de Souza Siqueira Quintans Lucindo José Quintans-Júnior Health functions and related molecular mechanisms of Miconia genus: A systematic review Heliyon Miconia Therapeutic mechanism Animal model Antioxidant Analgesic Anti-inflammatory |
| title | Health functions and related molecular mechanisms of Miconia genus: A systematic review |
| title_full | Health functions and related molecular mechanisms of Miconia genus: A systematic review |
| title_fullStr | Health functions and related molecular mechanisms of Miconia genus: A systematic review |
| title_full_unstemmed | Health functions and related molecular mechanisms of Miconia genus: A systematic review |
| title_short | Health functions and related molecular mechanisms of Miconia genus: A systematic review |
| title_sort | health functions and related molecular mechanisms of miconia genus a systematic review |
| topic | Miconia Therapeutic mechanism Animal model Antioxidant Analgesic Anti-inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023018169 |
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