Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China
IntroductionThe coronavirus disease-2019 (COVID-19) pandemic has swept across the world and continues to exert serious adverse effects on vulnerable populations, including pregnant women and neonates. The vaccines available at present were designed to prevent infection from COVID-19 strains and cont...
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1250165/full |
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| author | Yulu Yang Yulu Yang Yulu Yang Yujie Dong Yujie Dong Yujie Dong Guojing Li Guojing Li Guojing Li Guojing Li Biqi Yin Biqi Yin Biqi Yin Xiong Tang Xiong Tang Xiong Tang Liangfang Jia Xueke Zhang Xueke Zhang Xueke Zhang Xueke Zhang Wenjuan Yang Wenjuan Yang Wenjuan Yang Chao Wang Chao Wang Chao Wang Chao Wang Xiaoqing Peng Xiaoqing Peng Xiaoqing Peng Xiaoqing Peng Ying Zhang Ying Zhang Ying Zhang Yunxia Cao Yunxia Cao Yunxia Cao Xiaofeng Xu Xiaofeng Xu Xiaofeng Xu |
| author_facet | Yulu Yang Yulu Yang Yulu Yang Yujie Dong Yujie Dong Yujie Dong Guojing Li Guojing Li Guojing Li Guojing Li Biqi Yin Biqi Yin Biqi Yin Xiong Tang Xiong Tang Xiong Tang Liangfang Jia Xueke Zhang Xueke Zhang Xueke Zhang Xueke Zhang Wenjuan Yang Wenjuan Yang Wenjuan Yang Chao Wang Chao Wang Chao Wang Chao Wang Xiaoqing Peng Xiaoqing Peng Xiaoqing Peng Xiaoqing Peng Ying Zhang Ying Zhang Ying Zhang Yunxia Cao Yunxia Cao Yunxia Cao Xiaofeng Xu Xiaofeng Xu Xiaofeng Xu |
| author_sort | Yulu Yang |
| collection | DOAJ |
| description | IntroductionThe coronavirus disease-2019 (COVID-19) pandemic has swept across the world and continues to exert serious adverse effects on vulnerable populations, including pregnant women and neonates. The vaccines available at present were designed to prevent infection from COVID-19 strains and control viral spread. Although the incidence of pregnancy cycle outcomes are not likely to increase patients vaccinated prior to pregnancy compared with unvaccinated patients based on our knowledge of vaccination safety, there is no specific evidence to support this hypothesis. Therefore, the current study aimed to investigate the association between maternal vaccination prior to conception and pregnancy outcomes.MethodsWe retrospectively analyzed 2,614 women who received prenatal care and delivered in the Obstetrical Department of The First Affiliated Hospital of Anhui Medical University between February 2022 and November 2022. Of the 1,380 eligible pregnant women, 899 women who had received preconception vaccination were assigned to a vaccine group and 481 women who were not vaccinated were control group. Of the enrolled patients, 291 women received fertility treatment (141 vaccinated women, 150 unvaccinated women). The primary outcomes were pregnancy complications (hypothyroidism, gestational diabetes mellitus, pregnancy-induced hypertension, polyhydramnios, oligohydramnios, premature rupture of membranes and postpartum hemorrhage), obstetric outcomes (preterm birth rate, cesarean section rate) and neonatal outcomes (birth-weight, body length, low-birth-weight rate, rate of congenital defects, neonatal mortality and admission to the neonatal intensive care unit).ResultsThere was no significant difference in the incidence of complications during pregnancy and delivery when compared between the vaccine group and control group in either univariate- or multivariate-models. The type of vaccine was not associated with the odds of adverse pregnancy outcome. Among the women with infertility treatment, the vaccinated group and the unvaccinated group had similar pregnancy outcomes.ConclusionWomen who received COVID-19 vaccination prior to conception had similar maternal and neonatal outcomes as women who were unvaccinated. Our findings indicate that COVID-19 vaccinations can be safely administered prior to pregnancy in women who are planning pregnancy or assisted reproductive treatment. During new waves of COVID-19 infection, women who are planning pregnancy should be vaccinated as soon as possible to avoid subsequent infections. |
| first_indexed | 2024-03-11T18:52:18Z |
| format | Article |
| id | doaj.art-13543710f1f443bfa3d38519d5d68517 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-11T18:52:18Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-13543710f1f443bfa3d38519d5d685172023-10-11T08:29:11ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-10-011010.3389/fmed.2023.12501651250165Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in ChinaYulu Yang0Yulu Yang1Yulu Yang2Yujie Dong3Yujie Dong4Yujie Dong5Guojing Li6Guojing Li7Guojing Li8Guojing Li9Biqi Yin10Biqi Yin11Biqi Yin12Xiong Tang13Xiong Tang14Xiong Tang15Liangfang Jia16Xueke Zhang17Xueke Zhang18Xueke Zhang19Xueke Zhang20Wenjuan Yang21Wenjuan Yang22Wenjuan Yang23Chao Wang24Chao Wang25Chao Wang26Chao Wang27Xiaoqing Peng28Xiaoqing Peng29Xiaoqing Peng30Xiaoqing Peng31Ying Zhang32Ying Zhang33Ying Zhang34Yunxia Cao35Yunxia Cao36Yunxia Cao37Xiaofeng Xu38Xiaofeng Xu39Xiaofeng Xu40Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaDepartment of Clinical Medicine, The First School of Clinical Medicine, Anhui Medical University, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaDepartment of Obstetrics and Gynecology, The Hefei First People’s Hospital, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaDepartment of Clinical Medicine, The First School of Clinical Medicine, Anhui Medical University, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Reproductive Health and Genetics, Hefei, ChinaAnhui Provincial Engineering Research Center of Biopreservation and Artificial Organs, Hefei, ChinaAnhui Provincial Institute of Translational Medicine, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Reproductive Health and Genetics, Hefei, ChinaAnhui Provincial Engineering Research Center of Biopreservation and Artificial Organs, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaAnhui Provincial Institute of Translational Medicine, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaAnhui Provincial Institute of Translational Medicine, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, ChinaIntroductionThe coronavirus disease-2019 (COVID-19) pandemic has swept across the world and continues to exert serious adverse effects on vulnerable populations, including pregnant women and neonates. The vaccines available at present were designed to prevent infection from COVID-19 strains and control viral spread. Although the incidence of pregnancy cycle outcomes are not likely to increase patients vaccinated prior to pregnancy compared with unvaccinated patients based on our knowledge of vaccination safety, there is no specific evidence to support this hypothesis. Therefore, the current study aimed to investigate the association between maternal vaccination prior to conception and pregnancy outcomes.MethodsWe retrospectively analyzed 2,614 women who received prenatal care and delivered in the Obstetrical Department of The First Affiliated Hospital of Anhui Medical University between February 2022 and November 2022. Of the 1,380 eligible pregnant women, 899 women who had received preconception vaccination were assigned to a vaccine group and 481 women who were not vaccinated were control group. Of the enrolled patients, 291 women received fertility treatment (141 vaccinated women, 150 unvaccinated women). The primary outcomes were pregnancy complications (hypothyroidism, gestational diabetes mellitus, pregnancy-induced hypertension, polyhydramnios, oligohydramnios, premature rupture of membranes and postpartum hemorrhage), obstetric outcomes (preterm birth rate, cesarean section rate) and neonatal outcomes (birth-weight, body length, low-birth-weight rate, rate of congenital defects, neonatal mortality and admission to the neonatal intensive care unit).ResultsThere was no significant difference in the incidence of complications during pregnancy and delivery when compared between the vaccine group and control group in either univariate- or multivariate-models. The type of vaccine was not associated with the odds of adverse pregnancy outcome. Among the women with infertility treatment, the vaccinated group and the unvaccinated group had similar pregnancy outcomes.ConclusionWomen who received COVID-19 vaccination prior to conception had similar maternal and neonatal outcomes as women who were unvaccinated. Our findings indicate that COVID-19 vaccinations can be safely administered prior to pregnancy in women who are planning pregnancy or assisted reproductive treatment. During new waves of COVID-19 infection, women who are planning pregnancy should be vaccinated as soon as possible to avoid subsequent infections.https://www.frontiersin.org/articles/10.3389/fmed.2023.1250165/fullCOVID-19vaccinationsafetyobstetric outcomesneonatal outcomes |
| spellingShingle | Yulu Yang Yulu Yang Yulu Yang Yujie Dong Yujie Dong Yujie Dong Guojing Li Guojing Li Guojing Li Guojing Li Biqi Yin Biqi Yin Biqi Yin Xiong Tang Xiong Tang Xiong Tang Liangfang Jia Xueke Zhang Xueke Zhang Xueke Zhang Xueke Zhang Wenjuan Yang Wenjuan Yang Wenjuan Yang Chao Wang Chao Wang Chao Wang Chao Wang Xiaoqing Peng Xiaoqing Peng Xiaoqing Peng Xiaoqing Peng Ying Zhang Ying Zhang Ying Zhang Yunxia Cao Yunxia Cao Yunxia Cao Xiaofeng Xu Xiaofeng Xu Xiaofeng Xu Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China Frontiers in Medicine COVID-19 vaccination safety obstetric outcomes neonatal outcomes |
| title | Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China |
| title_full | Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China |
| title_fullStr | Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China |
| title_full_unstemmed | Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China |
| title_short | Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China |
| title_sort | pregnancy outcomes following natural conception and assisted reproduction treatment in women who received covid 19 vaccination prior to conception a population based cohort study in china |
| topic | COVID-19 vaccination safety obstetric outcomes neonatal outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1250165/full |
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