A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus
The aim of this study is to describe a new keratoconus detection method based on the analysis of certain parametric morphogeometric operators extracted from a custom patient-specific three-dimensional (3D) model of the human cornea. A corneal geometric reconstruction is firstly performed using zonal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | Symmetry |
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| Online Access: | https://www.mdpi.com/2073-8994/9/12/302 |
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| author | Laurent Bataille Francisco Cavas-Martínez Daniel G. Fernández-Pacheco Francisco J. F. Cañavate Jorge L. Alio |
| author_facet | Laurent Bataille Francisco Cavas-Martínez Daniel G. Fernández-Pacheco Francisco J. F. Cañavate Jorge L. Alio |
| author_sort | Laurent Bataille |
| collection | DOAJ |
| description | The aim of this study is to describe a new keratoconus detection method based on the analysis of certain parametric morphogeometric operators extracted from a custom patient-specific three-dimensional (3D) model of the human cornea. A corneal geometric reconstruction is firstly performed using zonal functions and retrospective Scheimpflug tomography data from 107 eyes of 107 patients. The posterior corneal surface is later analysed using an optimised computational geometry technique and the morphology of healthy and keratoconic corneas is characterized by means of geometric variables. The performance of these variables as predictors of a new geometric marker is assessed through a receiver operating characteristic (ROC) curve analysis and their correlations are analysed through Pearson or Spearman coefficients. The posterior apex deviation variable shows the best keratoconus diagnosis capability. However, the strongest correlations in both healthy and pathological corneas are provided by the metrics directly related to the thickness as the sagittal plane area at the apex and the sagittal plane area at the minimum thickness point. A comparison of the screening of keratoconus provided by the Sirius topographer and the detection of corneal ectasia using the posterior apex deviation parameter is also performed, demonstrating the accuracy of this characterization as an effective marker of the diagnosis and ectatic disease progression. |
| first_indexed | 2024-04-11T12:50:23Z |
| format | Article |
| id | doaj.art-1354951b22bb4f1eba4394bb10fa82c5 |
| institution | Directory Open Access Journal |
| issn | 2073-8994 |
| language | English |
| last_indexed | 2024-04-11T12:50:23Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Symmetry |
| spelling | doaj.art-1354951b22bb4f1eba4394bb10fa82c52022-12-22T04:23:13ZengMDPI AGSymmetry2073-89942017-12-0191230210.3390/sym9120302sym9120302A Study for Parametric Morphogeometric Operators to Assist the Detection of KeratoconusLaurent Bataille0Francisco Cavas-Martínez1Daniel G. Fernández-Pacheco2Francisco J. F. Cañavate3Jorge L. Alio4Department of Graphical Expression, Technical University of Cartagena, 30202 Cartagena, SpainDepartment of Graphical Expression, Technical University of Cartagena, 30202 Cartagena, SpainDepartment of Graphical Expression, Technical University of Cartagena, 30202 Cartagena, SpainDepartment of Graphical Expression, Technical University of Cartagena, 30202 Cartagena, SpainKeratoconus Unit of Vissum Corporation Alicante, 03016 Alicante, SpainThe aim of this study is to describe a new keratoconus detection method based on the analysis of certain parametric morphogeometric operators extracted from a custom patient-specific three-dimensional (3D) model of the human cornea. A corneal geometric reconstruction is firstly performed using zonal functions and retrospective Scheimpflug tomography data from 107 eyes of 107 patients. The posterior corneal surface is later analysed using an optimised computational geometry technique and the morphology of healthy and keratoconic corneas is characterized by means of geometric variables. The performance of these variables as predictors of a new geometric marker is assessed through a receiver operating characteristic (ROC) curve analysis and their correlations are analysed through Pearson or Spearman coefficients. The posterior apex deviation variable shows the best keratoconus diagnosis capability. However, the strongest correlations in both healthy and pathological corneas are provided by the metrics directly related to the thickness as the sagittal plane area at the apex and the sagittal plane area at the minimum thickness point. A comparison of the screening of keratoconus provided by the Sirius topographer and the detection of corneal ectasia using the posterior apex deviation parameter is also performed, demonstrating the accuracy of this characterization as an effective marker of the diagnosis and ectatic disease progression.https://www.mdpi.com/2073-8994/9/12/302geometric modellingcornea reconstructiondiagnosisScheimpflugcomputer-aided design |
| spellingShingle | Laurent Bataille Francisco Cavas-Martínez Daniel G. Fernández-Pacheco Francisco J. F. Cañavate Jorge L. Alio A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus Symmetry geometric modelling cornea reconstruction diagnosis Scheimpflug computer-aided design |
| title | A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus |
| title_full | A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus |
| title_fullStr | A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus |
| title_full_unstemmed | A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus |
| title_short | A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus |
| title_sort | study for parametric morphogeometric operators to assist the detection of keratoconus |
| topic | geometric modelling cornea reconstruction diagnosis Scheimpflug computer-aided design |
| url | https://www.mdpi.com/2073-8994/9/12/302 |
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