Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients?
Currently, there are no approved pharmacological treatments for the management of patients with idiopathic pulmonary fibrosis (IPF) in the USA or Europe. Pirfenidone is an orally bio-available small molecule that exhibits antifibrotic and anti-inflammatory properties in a variety of in vitro and ani...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2011-09-01
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| Series: | European Respiratory Review |
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| Online Access: | http://err.ersjournals.com/content/20/121/201.full.pdf+html |
| _version_ | 1811245148380594176 |
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| author | U. Costabel |
| author_facet | U. Costabel |
| author_sort | U. Costabel |
| collection | DOAJ |
| description | Currently, there are no approved pharmacological treatments for the management of patients with idiopathic pulmonary fibrosis (IPF) in the USA or Europe. Pirfenidone is an orally bio-available small molecule that exhibits antifibrotic and anti-inflammatory properties in a variety of in vitro and animal models. Pirfenidone has been evaluated in four randomised, double-blind, placebo-controlled clinical trials conducted in Japan, North America and Europe. The totality of the data from these trials indicates that pirfenidone is able to reduce the rate of decline in lung function, measured as change in per cent predicted forced vital capacity (FVC) or vital capacity. There was also an effect on secondary end-points of progression free survival, categorical change in per cent predicted FVC, and the 6-min walk test. A recent meta-analysis of the three phase III studies in IPF demonstrated that pirfenidone significantly reduced the risk of disease progression by 30%. The efficacy of pirfenidone is associated with an acceptable tolerability and safety profile. |
| first_indexed | 2024-04-12T14:35:50Z |
| format | Article |
| id | doaj.art-135646e6108a46aba6b2faff8f107295 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-04-12T14:35:50Z |
| publishDate | 2011-09-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-135646e6108a46aba6b2faff8f1072952022-12-22T03:29:05ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172011-09-0120121201207Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients?U. CostabelCurrently, there are no approved pharmacological treatments for the management of patients with idiopathic pulmonary fibrosis (IPF) in the USA or Europe. Pirfenidone is an orally bio-available small molecule that exhibits antifibrotic and anti-inflammatory properties in a variety of in vitro and animal models. Pirfenidone has been evaluated in four randomised, double-blind, placebo-controlled clinical trials conducted in Japan, North America and Europe. The totality of the data from these trials indicates that pirfenidone is able to reduce the rate of decline in lung function, measured as change in per cent predicted forced vital capacity (FVC) or vital capacity. There was also an effect on secondary end-points of progression free survival, categorical change in per cent predicted FVC, and the 6-min walk test. A recent meta-analysis of the three phase III studies in IPF demonstrated that pirfenidone significantly reduced the risk of disease progression by 30%. The efficacy of pirfenidone is associated with an acceptable tolerability and safety profile.http://err.ersjournals.com/content/20/121/201.full.pdf+htmlIdiopathic pulmonary fibrosismeta-analysisN-acetylcysteinepirfenidoneprogression-free survivalvital capacity |
| spellingShingle | U. Costabel Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients? European Respiratory Review Idiopathic pulmonary fibrosis meta-analysis N-acetylcysteine pirfenidone progression-free survival vital capacity |
| title | Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients? |
| title_full | Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients? |
| title_fullStr | Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients? |
| title_full_unstemmed | Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients? |
| title_short | Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients? |
| title_sort | emerging potential treatments new hope for idiopathic pulmonary fibrosis patients |
| topic | Idiopathic pulmonary fibrosis meta-analysis N-acetylcysteine pirfenidone progression-free survival vital capacity |
| url | http://err.ersjournals.com/content/20/121/201.full.pdf+html |
| work_keys_str_mv | AT ucostabel emergingpotentialtreatmentsnewhopeforidiopathicpulmonaryfibrosispatients |