Effect of atropine 0.01% on myopia control in children aged 6–13 years during the 2022 lockdown in Shanghai
PurposeTo compare the myopic progression in children treated with 0. 01% atropine and those who discontinued atropine during the 2022-home quarantine in Shanghai.MethodsIn this retrospective study, children aged 6–13 years with follow-up visits before (between January 2022 and February 2022) and aft...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1074272/full |
| _version_ | 1797942789276696576 |
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| author | Manrong Yu Manrong Yu Manrong Yu Manrong Yu Lingli Jiang Minjie Chen Minjie Chen Minjie Chen Minjie Chen |
| author_facet | Manrong Yu Manrong Yu Manrong Yu Manrong Yu Lingli Jiang Minjie Chen Minjie Chen Minjie Chen Minjie Chen |
| author_sort | Manrong Yu |
| collection | DOAJ |
| description | PurposeTo compare the myopic progression in children treated with 0. 01% atropine and those who discontinued atropine during the 2022-home quarantine in Shanghai.MethodsIn this retrospective study, children aged 6–13 years with follow-up visits before (between January 2022 and February 2022) and after the lockdown (between July 2022 and August 2022) were included. Cycloplegic refraction and axial length (AL) were measured at both visits. The atropine group had continuous medication during the lockdown while the control group discontinued. The 0.01% atropine eyedrops were administered daily before bedtime. The types of spectacle lens were recorded: single vision (SV) spectacles or defocus incorporated multiple segments lenses (DIMS).ResultsIn total, 41 children (81 eyes) in the atropine group and 32 children (64 eyes) in the control group were enrolled. No significant difference was found in the demographic characteristics, spherical diopter, spherical equivalent (SE), AL, and follow-up time between the two groups before the lockdown in 2022 (all p > 0.1). After the home confinement, a greater myopia progression was observed in the control group (−0.46 ± 0.42 D) compared to atropine group (−0.26 ± 0.37 D; p = 0.0023). Axial elongation was also longer in the control group than that in children sustained with atropine (0.21 ± 0.17 vs. 0.13 ± 0.15 mm, p = 0.0035). Moreover, there was no significant change of spherical diopter and SE during lockdown in the atropine + DIMS combined subgroup (0.03 ± 0.033 D for spherical diopter, p = 0.7261 and 0.08 ± 0.27 D for SE, p = 0.2042, respectively). However, significant myopic shift was observed in the atropine + SV subgroup during the quarantine time (−0.31 ± 0.39 D for SE and 0.15 ± 0.16 mm for AL, both p < 0.001).ConclusionChildren treated with 0.01% atropine had slower myopia progression during the lockdown period in Shanghai compared with children discontinued. Moreover, the effect of atropine on myopic prevention can be strengthened with DIMS lenses. |
| first_indexed | 2024-04-10T20:13:08Z |
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| id | doaj.art-1357480cb92c4a1cab376b0d5d0d2209 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-10T20:13:08Z |
| publishDate | 2023-01-01 |
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| spelling | doaj.art-1357480cb92c4a1cab376b0d5d0d22092023-01-26T07:49:19ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-01-011110.3389/fpubh.2023.10742721074272Effect of atropine 0.01% on myopia control in children aged 6–13 years during the 2022 lockdown in ShanghaiManrong Yu0Manrong Yu1Manrong Yu2Manrong Yu3Lingli Jiang4Minjie Chen5Minjie Chen6Minjie Chen7Minjie Chen8Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Visual Impairment and Restoration of Shanghai, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia, Fudan University, Shanghai, ChinaKey Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, ChinaDepartment of Ophthalmology, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, ChinaDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Visual Impairment and Restoration of Shanghai, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia, Fudan University, Shanghai, ChinaKey Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, ChinaPurposeTo compare the myopic progression in children treated with 0. 01% atropine and those who discontinued atropine during the 2022-home quarantine in Shanghai.MethodsIn this retrospective study, children aged 6–13 years with follow-up visits before (between January 2022 and February 2022) and after the lockdown (between July 2022 and August 2022) were included. Cycloplegic refraction and axial length (AL) were measured at both visits. The atropine group had continuous medication during the lockdown while the control group discontinued. The 0.01% atropine eyedrops were administered daily before bedtime. The types of spectacle lens were recorded: single vision (SV) spectacles or defocus incorporated multiple segments lenses (DIMS).ResultsIn total, 41 children (81 eyes) in the atropine group and 32 children (64 eyes) in the control group were enrolled. No significant difference was found in the demographic characteristics, spherical diopter, spherical equivalent (SE), AL, and follow-up time between the two groups before the lockdown in 2022 (all p > 0.1). After the home confinement, a greater myopia progression was observed in the control group (−0.46 ± 0.42 D) compared to atropine group (−0.26 ± 0.37 D; p = 0.0023). Axial elongation was also longer in the control group than that in children sustained with atropine (0.21 ± 0.17 vs. 0.13 ± 0.15 mm, p = 0.0035). Moreover, there was no significant change of spherical diopter and SE during lockdown in the atropine + DIMS combined subgroup (0.03 ± 0.033 D for spherical diopter, p = 0.7261 and 0.08 ± 0.27 D for SE, p = 0.2042, respectively). However, significant myopic shift was observed in the atropine + SV subgroup during the quarantine time (−0.31 ± 0.39 D for SE and 0.15 ± 0.16 mm for AL, both p < 0.001).ConclusionChildren treated with 0.01% atropine had slower myopia progression during the lockdown period in Shanghai compared with children discontinued. Moreover, the effect of atropine on myopic prevention can be strengthened with DIMS lenses.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1074272/fullmyopia controlatropineCOVID-19Shanghaimyopia progressionquarantine |
| spellingShingle | Manrong Yu Manrong Yu Manrong Yu Manrong Yu Lingli Jiang Minjie Chen Minjie Chen Minjie Chen Minjie Chen Effect of atropine 0.01% on myopia control in children aged 6–13 years during the 2022 lockdown in Shanghai Frontiers in Public Health myopia control atropine COVID-19 Shanghai myopia progression quarantine |
| title | Effect of atropine 0.01% on myopia control in children aged 6–13 years during the 2022 lockdown in Shanghai |
| title_full | Effect of atropine 0.01% on myopia control in children aged 6–13 years during the 2022 lockdown in Shanghai |
| title_fullStr | Effect of atropine 0.01% on myopia control in children aged 6–13 years during the 2022 lockdown in Shanghai |
| title_full_unstemmed | Effect of atropine 0.01% on myopia control in children aged 6–13 years during the 2022 lockdown in Shanghai |
| title_short | Effect of atropine 0.01% on myopia control in children aged 6–13 years during the 2022 lockdown in Shanghai |
| title_sort | effect of atropine 0 01 on myopia control in children aged 6 13 years during the 2022 lockdown in shanghai |
| topic | myopia control atropine COVID-19 Shanghai myopia progression quarantine |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1074272/full |
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