RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis
Summary: Voluntary running enhances adult hippocampal neurogenesis, with consequences for hippocampal-dependent learning ability and mood regulation. However, the underlying mechanism remains unclear. Here, we show that voluntary running induces unique and dynamic gene expression changes specificall...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124720309827 |
| _version_ | 1819319181205569536 |
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| author | Yu Gao Minjie Shen Jose Carlos Gonzalez Qiping Dong Sudharsan Kannan Johnson T. Hoang Brian E. Eisinger Jyotsna Pandey Sahar Javadi Qiang Chang Daifeng Wang Linda Overstreet-Wadiche Xinyu Zhao |
| author_facet | Yu Gao Minjie Shen Jose Carlos Gonzalez Qiping Dong Sudharsan Kannan Johnson T. Hoang Brian E. Eisinger Jyotsna Pandey Sahar Javadi Qiang Chang Daifeng Wang Linda Overstreet-Wadiche Xinyu Zhao |
| author_sort | Yu Gao |
| collection | DOAJ |
| description | Summary: Voluntary running enhances adult hippocampal neurogenesis, with consequences for hippocampal-dependent learning ability and mood regulation. However, the underlying mechanism remains unclear. Here, we show that voluntary running induces unique and dynamic gene expression changes specifically within the adult-born hippocampal neurons, with significant impact on genes involved in neuronal maturation and human diseases. We identify the regulator of G protein signaling 6 (RGS6) as a key factor that mediates running impact on adult-born neurons. RGS6 overexpression mimics the positive effects of voluntary running on morphological and physiological maturation of adult new neurons and reduced sensitivity of adult-born neurons to the inhibitory effect of GABAB (γ-Aminobutyric acid B) receptor activation. Knocking down RGS6 abolishes running-enhanced neuronal maturation and hippocampal neurogenesis-dependent learning and anxiolytic effect. Our study provides a data resource showing genome-wide intrinsic molecular changes in adult-born hippocampal neurons that contribute to voluntary running-induced neurogenesis. |
| first_indexed | 2024-12-24T10:59:36Z |
| format | Article |
| id | doaj.art-13585a4fa64043f193dcb2306c023105 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-24T10:59:36Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-13585a4fa64043f193dcb2306c0231052022-12-21T16:58:45ZengElsevierCell Reports2211-12472020-08-01325107997RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal NeurogenesisYu Gao0Minjie Shen1Jose Carlos Gonzalez2Qiping Dong3Sudharsan Kannan4Johnson T. Hoang5Brian E. Eisinger6Jyotsna Pandey7Sahar Javadi8Qiang Chang9Daifeng Wang10Linda Overstreet-Wadiche11Xinyu Zhao12Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USADepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USADepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USAWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Corresponding authorSummary: Voluntary running enhances adult hippocampal neurogenesis, with consequences for hippocampal-dependent learning ability and mood regulation. However, the underlying mechanism remains unclear. Here, we show that voluntary running induces unique and dynamic gene expression changes specifically within the adult-born hippocampal neurons, with significant impact on genes involved in neuronal maturation and human diseases. We identify the regulator of G protein signaling 6 (RGS6) as a key factor that mediates running impact on adult-born neurons. RGS6 overexpression mimics the positive effects of voluntary running on morphological and physiological maturation of adult new neurons and reduced sensitivity of adult-born neurons to the inhibitory effect of GABAB (γ-Aminobutyric acid B) receptor activation. Knocking down RGS6 abolishes running-enhanced neuronal maturation and hippocampal neurogenesis-dependent learning and anxiolytic effect. Our study provides a data resource showing genome-wide intrinsic molecular changes in adult-born hippocampal neurons that contribute to voluntary running-induced neurogenesis.http://www.sciencedirect.com/science/article/pii/S2211124720309827adult neurogenesisRgs6voluntary runningRiboTag-seqhippocampusneuronal maturation |
| spellingShingle | Yu Gao Minjie Shen Jose Carlos Gonzalez Qiping Dong Sudharsan Kannan Johnson T. Hoang Brian E. Eisinger Jyotsna Pandey Sahar Javadi Qiang Chang Daifeng Wang Linda Overstreet-Wadiche Xinyu Zhao RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis Cell Reports adult neurogenesis Rgs6 voluntary running RiboTag-seq hippocampus neuronal maturation |
| title | RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis |
| title_full | RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis |
| title_fullStr | RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis |
| title_full_unstemmed | RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis |
| title_short | RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis |
| title_sort | rgs6 mediates effects of voluntary running on adult hippocampal neurogenesis |
| topic | adult neurogenesis Rgs6 voluntary running RiboTag-seq hippocampus neuronal maturation |
| url | http://www.sciencedirect.com/science/article/pii/S2211124720309827 |
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