Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering
Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tiss...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/8/11/137 |
| _version_ | 1797509904053829632 |
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| author | Astha Khanna Maedeh Zamani Ngan F. Huang |
| author_facet | Astha Khanna Maedeh Zamani Ngan F. Huang |
| author_sort | Astha Khanna |
| collection | DOAJ |
| description | Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs. In this review, we summarize the in vitro, pre-clinical, and clinical research models that have been employed in the design of ECM-based biomaterials for cardiovascular regenerative medicine. We highlight the research advancements in the incorporation of ECM components into biomaterial-based scaffolds, the engineering of increasingly complex structures using biofabrication and spatial patterning techniques, the regulation of ECMs on vascular differentiation and function, and the translation of ECM-based scaffolds for vascular graft applications. Finally, we discuss the challenges, future perspectives, and directions in the design of next-generation ECM-based biomaterials for cardiovascular tissue engineering and clinical translation. |
| first_indexed | 2024-03-10T05:24:20Z |
| format | Article |
| id | doaj.art-1359a94f9a6746b89afc83a54e83fed8 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T05:24:20Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-1359a94f9a6746b89afc83a54e83fed82023-11-22T23:47:45ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-10-0181113710.3390/jcdd8110137Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue EngineeringAstha Khanna0Maedeh Zamani1Ngan F. Huang2Graver Technologies, Newark, NJ 07105, USADepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USADepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USARegenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs. In this review, we summarize the in vitro, pre-clinical, and clinical research models that have been employed in the design of ECM-based biomaterials for cardiovascular regenerative medicine. We highlight the research advancements in the incorporation of ECM components into biomaterial-based scaffolds, the engineering of increasingly complex structures using biofabrication and spatial patterning techniques, the regulation of ECMs on vascular differentiation and function, and the translation of ECM-based scaffolds for vascular graft applications. Finally, we discuss the challenges, future perspectives, and directions in the design of next-generation ECM-based biomaterials for cardiovascular tissue engineering and clinical translation.https://www.mdpi.com/2308-3425/8/11/137tissue engineeringregenerative medicineextracellular matrix (ECM) |
| spellingShingle | Astha Khanna Maedeh Zamani Ngan F. Huang Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering Journal of Cardiovascular Development and Disease tissue engineering regenerative medicine extracellular matrix (ECM) |
| title | Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering |
| title_full | Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering |
| title_fullStr | Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering |
| title_full_unstemmed | Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering |
| title_short | Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering |
| title_sort | extracellular matrix based biomaterials for cardiovascular tissue engineering |
| topic | tissue engineering regenerative medicine extracellular matrix (ECM) |
| url | https://www.mdpi.com/2308-3425/8/11/137 |
| work_keys_str_mv | AT asthakhanna extracellularmatrixbasedbiomaterialsforcardiovasculartissueengineering AT maedehzamani extracellularmatrixbasedbiomaterialsforcardiovasculartissueengineering AT nganfhuang extracellularmatrixbasedbiomaterialsforcardiovasculartissueengineering |