The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patients
Abstract Primary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS patien...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17354-1 |
| _version_ | 1828327794125307904 |
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| author | Radjiv Goulabchand Elodie Castille Sophie Navucet Damien Etchecopar-Etchart Aurélie Matos Alexandre Maria Laure Anne Gutierrez Alain Le Quellec Nicolas Menjot de Champfleur Audrey Gabelle Philippe Guilpain |
| author_facet | Radjiv Goulabchand Elodie Castille Sophie Navucet Damien Etchecopar-Etchart Aurélie Matos Alexandre Maria Laure Anne Gutierrez Alain Le Quellec Nicolas Menjot de Champfleur Audrey Gabelle Philippe Guilpain |
| author_sort | Radjiv Goulabchand |
| collection | DOAJ |
| description | Abstract Primary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS patients with memory complaints were included, prospectively. Cognitive profiles were compiled through a comprehensive cognitive evaluation by neuropsychologists. Evaluations of anxiety, depression, fatigue, sleep disorders and quality of life were performed for testing their interactions with cognitive profiles. All 32 pSS patients showed at least borderline cognitive impairment, and 17 (53%) exhibited a pathological cognitive profile: a hippocampal profile (37%), a dysexecutive profile (22%), and an instrumental profile (16%) (possible overlap). Regarding the secondary objectives: 37% of patients were depressed, and 48% exhibited a mild-to-severe anxiety trait. Sleep disorders were frequent (excessive daytime sleepiness (55%), high risk for sleep apnea (45%), and insomnia (77%)). Cognitive impairments could not be explained alone by anxiety, depression or sleep disorders. Fatigue level was strongly associated with sleep disorders. Our study highlights that cognitive complaints in pSS patients are supported by measurable cognitive impairments, apart from frequently associated disorders such as depression, anxiety or sleep troubles. Sleep disorders should be screened. |
| first_indexed | 2024-04-13T19:59:54Z |
| format | Article |
| id | doaj.art-135b4d0281c5421bb1e4cd88b49e400a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T19:59:54Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-135b4d0281c5421bb1e4cd88b49e400a2022-12-22T02:32:13ZengNature PortfolioScientific Reports2045-23222022-08-0112111210.1038/s41598-022-17354-1The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patientsRadjiv Goulabchand0Elodie Castille1Sophie Navucet2Damien Etchecopar-Etchart3Aurélie Matos4Alexandre Maria5Laure Anne Gutierrez6Alain Le Quellec7Nicolas Menjot de Champfleur8Audrey Gabelle9Philippe Guilpain10Internal Medicine Department, CHU NîmesUniversity of MontpellierDepartment of Neurology, Memory Research and Resources Alzheimer Center, Gui de Chauliac Hospital, Montpellier University HospitalFaculté de Médecine-Secteur Timone, EA 3279: CEReSS-Centre d’Etude et de Recherche sur les Services de Santé et la Qualité de vie, Aix-Marseille UniversitéDepartment of Neurology, Memory Research and Resources Alzheimer Center, Gui de Chauliac Hospital, Montpellier University HospitalUniversity of MontpellierUniversity of MontpellierUniversity of MontpellierDepartment of Neuroradiology, I2FH, Institut d’Imagerie Fonctionnelle Humaine, Gui de Chauliac Hospital, Montpellier University HospitalUniversity of MontpellierUniversity of MontpellierAbstract Primary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS patients with memory complaints were included, prospectively. Cognitive profiles were compiled through a comprehensive cognitive evaluation by neuropsychologists. Evaluations of anxiety, depression, fatigue, sleep disorders and quality of life were performed for testing their interactions with cognitive profiles. All 32 pSS patients showed at least borderline cognitive impairment, and 17 (53%) exhibited a pathological cognitive profile: a hippocampal profile (37%), a dysexecutive profile (22%), and an instrumental profile (16%) (possible overlap). Regarding the secondary objectives: 37% of patients were depressed, and 48% exhibited a mild-to-severe anxiety trait. Sleep disorders were frequent (excessive daytime sleepiness (55%), high risk for sleep apnea (45%), and insomnia (77%)). Cognitive impairments could not be explained alone by anxiety, depression or sleep disorders. Fatigue level was strongly associated with sleep disorders. Our study highlights that cognitive complaints in pSS patients are supported by measurable cognitive impairments, apart from frequently associated disorders such as depression, anxiety or sleep troubles. Sleep disorders should be screened.https://doi.org/10.1038/s41598-022-17354-1 |
| spellingShingle | Radjiv Goulabchand Elodie Castille Sophie Navucet Damien Etchecopar-Etchart Aurélie Matos Alexandre Maria Laure Anne Gutierrez Alain Le Quellec Nicolas Menjot de Champfleur Audrey Gabelle Philippe Guilpain The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patients Scientific Reports |
| title | The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patients |
| title_full | The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patients |
| title_fullStr | The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patients |
| title_full_unstemmed | The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patients |
| title_short | The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patients |
| title_sort | interplay between cognition depression anxiety and sleep in primary sjogren s syndrome patients |
| url | https://doi.org/10.1038/s41598-022-17354-1 |
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