Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals
Major depressive disorder and bipolar disorder are the leading causes of global disability. Approximately 50% of patients fail to attain remission, prompting a pronounced focus on the significance of dietary patterns and specific nutrients within the pathophysiology of mood disorders. The connection...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/9/1262 |
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| author | Agnieszka Mechlińska Mariusz S. Wiglusz Jakub Słupski Adam Włodarczyk Wiesław J. Cubała |
| author_facet | Agnieszka Mechlińska Mariusz S. Wiglusz Jakub Słupski Adam Włodarczyk Wiesław J. Cubała |
| author_sort | Agnieszka Mechlińska |
| collection | DOAJ |
| description | Major depressive disorder and bipolar disorder are the leading causes of global disability. Approximately 50% of patients fail to attain remission, prompting a pronounced focus on the significance of dietary patterns and specific nutrients within the pathophysiology of mood disorders. The connection between chronic diseases and mood disorders follows a bidirectional pattern: physical ailments are interrelated with affective disorders, and, concurrently, mood symptoms often precede chronic diseases and have the potential to worsen their prognosis. Nutraceuticals affect factors that could potentially impact the onset of mood disorders: monoamines and brain-derived neurotrophic factor (BDNF) concentrations, neuroinflammation, oxidative stress, and sleep quality. Furthermore, mood disorders rarely manifest in isolation. Typically, such patients concurrently experience other mental disorders or somatic comorbidities: obesity, hypertension, diabetes, polycystic ovary syndrome (PCOS), etc., where providing nutritional support is also pertinent. To optimize the therapeutic approach for individuals with mood disorders, incorporating nutritional support may not solely ameliorate symptoms stemming directly from the mental condition, but also indirectly through interventions targeting comorbidities. |
| first_indexed | 2024-03-10T22:59:00Z |
| format | Article |
| id | doaj.art-135bf614e8ec4fc0969f96ae50ad0e50 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T22:59:00Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-135bf614e8ec4fc0969f96ae50ad0e502023-11-19T09:48:29ZengMDPI AGBrain Sciences2076-34252023-08-01139126210.3390/brainsci13091262Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on NutraceuticalsAgnieszka Mechlińska0Mariusz S. Wiglusz1Jakub Słupski2Adam Włodarczyk3Wiesław J. Cubała4Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, PolandDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, PolandDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, PolandDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, PolandDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, PolandMajor depressive disorder and bipolar disorder are the leading causes of global disability. Approximately 50% of patients fail to attain remission, prompting a pronounced focus on the significance of dietary patterns and specific nutrients within the pathophysiology of mood disorders. The connection between chronic diseases and mood disorders follows a bidirectional pattern: physical ailments are interrelated with affective disorders, and, concurrently, mood symptoms often precede chronic diseases and have the potential to worsen their prognosis. Nutraceuticals affect factors that could potentially impact the onset of mood disorders: monoamines and brain-derived neurotrophic factor (BDNF) concentrations, neuroinflammation, oxidative stress, and sleep quality. Furthermore, mood disorders rarely manifest in isolation. Typically, such patients concurrently experience other mental disorders or somatic comorbidities: obesity, hypertension, diabetes, polycystic ovary syndrome (PCOS), etc., where providing nutritional support is also pertinent. To optimize the therapeutic approach for individuals with mood disorders, incorporating nutritional support may not solely ameliorate symptoms stemming directly from the mental condition, but also indirectly through interventions targeting comorbidities.https://www.mdpi.com/2076-3425/13/9/1262major depressive disorderbipolar disordernutraceuticalscomorbiditynutritional support |
| spellingShingle | Agnieszka Mechlińska Mariusz S. Wiglusz Jakub Słupski Adam Włodarczyk Wiesław J. Cubała Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals Brain Sciences major depressive disorder bipolar disorder nutraceuticals comorbidity nutritional support |
| title | Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals |
| title_full | Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals |
| title_fullStr | Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals |
| title_full_unstemmed | Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals |
| title_short | Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals |
| title_sort | exploring the relationship between mood disorders and coexisting health conditions the focus on nutraceuticals |
| topic | major depressive disorder bipolar disorder nutraceuticals comorbidity nutritional support |
| url | https://www.mdpi.com/2076-3425/13/9/1262 |
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