Oxidative Stress, Diet and Prostate Cancer
Prostate cancer has become the second leading cancer in men worldwide. Androgen plays an important role in normal functioning, development, and differentiation of the prostate, and thus is considered to be the most powerful candidate that mediates reactive oxygen species (ROS) balance in the prost...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2021-04-01
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| Series: | The World Journal of Men's Health |
| Subjects: |
| _version_ | 1818859324135440384 |
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| author | Bee Ling Tan Mohd Esa Norhaizan |
| author_facet | Bee Ling Tan Mohd Esa Norhaizan |
| author_sort | Bee Ling Tan |
| collection | DOAJ |
| description | Prostate cancer has become the second leading cancer in men worldwide. Androgen plays an important role in normal functioning,
development, and differentiation of the prostate, and thus is considered to be the most powerful candidate that mediates
reactive oxygen species (ROS) balance in the prostate. The elevation of ROS has been associated with the progression
and development of this disease. Conventional therapy has shown a high cure rate in patients with localized prostate cancer.
Despite the patients respond favorably initially, this therapy fails to response in the advanced stage of the diseases even in the
absence of androgens. Indeed, the onset and progression of prostate cancer could be prevented by changing dietary habits.
Much information indicates that oxidative stress and prostate cancer can be modulated by dietary components rich in antioxidants.
While there is substantial evidence to suggest an association between prostate cancer risk and ROS-mediated oxidative
stress; therefore, the interactions and mechanisms of this phenomenon are worth to discuss further. This review aimed to
discuss the mechanisms of action of oxidative stress involved in the progression of prostate cancer. We also highlighted how
some of the vital dietary components dampen or exacerbate inflammation, oxidative stress, and prostate cancer. Overall, the
reported information would provide a useful approach to the prevention of prostate cancer. |
| first_indexed | 2024-12-19T09:10:22Z |
| format | Article |
| id | doaj.art-135d7cdedd034eb18f8ee7b108c52331 |
| institution | Directory Open Access Journal |
| issn | 2287-4208 2287-4690 |
| language | English |
| last_indexed | 2024-12-19T09:10:22Z |
| publishDate | 2021-04-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj.art-135d7cdedd034eb18f8ee7b108c523312022-12-21T20:28:12ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902021-04-0139219520710.5534/wjmh.200014Oxidative Stress, Diet and Prostate CancerBee Ling Tan0https://orcid.org/0000-0003-3459-2967Mohd Esa Norhaizan1https://orcid.org/0000-0003-1545-0306Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaDepartment of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaProstate cancer has become the second leading cancer in men worldwide. Androgen plays an important role in normal functioning, development, and differentiation of the prostate, and thus is considered to be the most powerful candidate that mediates reactive oxygen species (ROS) balance in the prostate. The elevation of ROS has been associated with the progression and development of this disease. Conventional therapy has shown a high cure rate in patients with localized prostate cancer. Despite the patients respond favorably initially, this therapy fails to response in the advanced stage of the diseases even in the absence of androgens. Indeed, the onset and progression of prostate cancer could be prevented by changing dietary habits. Much information indicates that oxidative stress and prostate cancer can be modulated by dietary components rich in antioxidants. While there is substantial evidence to suggest an association between prostate cancer risk and ROS-mediated oxidative stress; therefore, the interactions and mechanisms of this phenomenon are worth to discuss further. This review aimed to discuss the mechanisms of action of oxidative stress involved in the progression of prostate cancer. We also highlighted how some of the vital dietary components dampen or exacerbate inflammation, oxidative stress, and prostate cancer. Overall, the reported information would provide a useful approach to the prevention of prostate cancer.inflammationoxidative stressphytochemicalsprostatereactive oxygen species |
| spellingShingle | Bee Ling Tan Mohd Esa Norhaizan Oxidative Stress, Diet and Prostate Cancer The World Journal of Men's Health inflammation oxidative stress phytochemicals prostate reactive oxygen species |
| title | Oxidative Stress, Diet and Prostate Cancer |
| title_full | Oxidative Stress, Diet and Prostate Cancer |
| title_fullStr | Oxidative Stress, Diet and Prostate Cancer |
| title_full_unstemmed | Oxidative Stress, Diet and Prostate Cancer |
| title_short | Oxidative Stress, Diet and Prostate Cancer |
| title_sort | oxidative stress diet and prostate cancer |
| topic | inflammation oxidative stress phytochemicals prostate reactive oxygen species |
| work_keys_str_mv | AT beelingtan oxidativestressdietandprostatecancer AT mohdesanorhaizan oxidativestressdietandprostatecancer |