Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection
Chronic cases of chikungunya fever represent a public health problem in countries where the virus circulates. The disease is prolonged, in some cases, for years, resulting in disabling pain and bone erosion among other bone and joint problems. As time progresses, tissue damage is persistent, althoug...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13087 |
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| author | Amanda M. Avila-Trejo Lorena I. Rodríguez-Páez Verónica Alcántara-Farfán J. Leopoldo Aguilar-Faisal |
| author_facet | Amanda M. Avila-Trejo Lorena I. Rodríguez-Páez Verónica Alcántara-Farfán J. Leopoldo Aguilar-Faisal |
| author_sort | Amanda M. Avila-Trejo |
| collection | DOAJ |
| description | Chronic cases of chikungunya fever represent a public health problem in countries where the virus circulates. The disease is prolonged, in some cases, for years, resulting in disabling pain and bone erosion among other bone and joint problems. As time progresses, tissue damage is persistent, although the virus has not been found in blood or joints. The pathogenesis of these conditions has not been fully explained. Additionally, it has been considered that there are multiple factors that might intervene in the viral pathogenesis of the different conditions that develop. Other mechanisms involved in osteoarthritic diseases of non-viral origin could help explain how damage is produced in chronic conditions. The aim of this review is to analyze the molecular and cellular factors that could be involved in the tissue damage generated by different infectious conditions of the chikungunya virus. |
| first_indexed | 2024-03-10T23:22:15Z |
| format | Article |
| id | doaj.art-135ed62de9aa42fca8b3716a62ba2d5b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:22:15Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-135ed62de9aa42fca8b3716a62ba2d5b2023-11-19T08:12:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171308710.3390/ijms241713087Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus InfectionAmanda M. Avila-Trejo0Lorena I. Rodríguez-Páez1Verónica Alcántara-Farfán2J. Leopoldo Aguilar-Faisal3Laboratorio de Bioquímica Farmacológica, Departamento de Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, MexicoLaboratorio de Bioquímica Farmacológica, Departamento de Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, MexicoLaboratorio de Bioquímica Farmacológica, Departamento de Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, MexicoLaboratorio de Medicina de Conservación, Secretaría de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoChronic cases of chikungunya fever represent a public health problem in countries where the virus circulates. The disease is prolonged, in some cases, for years, resulting in disabling pain and bone erosion among other bone and joint problems. As time progresses, tissue damage is persistent, although the virus has not been found in blood or joints. The pathogenesis of these conditions has not been fully explained. Additionally, it has been considered that there are multiple factors that might intervene in the viral pathogenesis of the different conditions that develop. Other mechanisms involved in osteoarthritic diseases of non-viral origin could help explain how damage is produced in chronic conditions. The aim of this review is to analyze the molecular and cellular factors that could be involved in the tissue damage generated by different infectious conditions of the chikungunya virus.https://www.mdpi.com/1422-0067/24/17/13087chikungunyaalphavirusbone damagebone resorption |
| spellingShingle | Amanda M. Avila-Trejo Lorena I. Rodríguez-Páez Verónica Alcántara-Farfán J. Leopoldo Aguilar-Faisal Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection International Journal of Molecular Sciences chikungunya alphavirus bone damage bone resorption |
| title | Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection |
| title_full | Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection |
| title_fullStr | Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection |
| title_full_unstemmed | Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection |
| title_short | Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection |
| title_sort | multiple factors involved in bone damage caused by chikungunya virus infection |
| topic | chikungunya alphavirus bone damage bone resorption |
| url | https://www.mdpi.com/1422-0067/24/17/13087 |
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