The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis
Aim. To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS. Materials and methods. The serum activities of the PM enzymes: xanthine oxidase (XO), guan...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2010-04-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30591 |
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| author | Aleksandr Borisovich Zborovskiy Elena Eduardovna Mozgovaya Vladislav Fedorovich Martem'yanov Ol'ga Petrovna Slyusar' Mikhail Yur'evich Stazharov S A Bedina A B Zborovsky E E Mozgovaya V F Martemyanov O P Slyusar M Yu Stazharov S A Bedina |
| author_facet | Aleksandr Borisovich Zborovskiy Elena Eduardovna Mozgovaya Vladislav Fedorovich Martem'yanov Ol'ga Petrovna Slyusar' Mikhail Yur'evich Stazharov S A Bedina A B Zborovsky E E Mozgovaya V F Martemyanov O P Slyusar M Yu Stazharov S A Bedina |
| author_sort | Aleksandr Borisovich Zborovskiy |
| collection | DOAJ |
| description | Aim. To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS.
Materials and methods. The serum activities of the PM enzymes: xanthine oxidase (XO), guanine deaminase (GDA), guanosine deaminase (GSDA), purine nucleoside phosphorylase (PNP), guanosine phosphorylase (GP), and adenosine deaminase (ADA) were determined in 55 patients (51 males and 4 females) aged 36.0 ± 1.4 years). A control group comprised 30 apparently age- and gender-matched healthy individuals, as in the study group.
Results. On admission, the patients were found to have increased XO, GDA, PNP, and GD activities and decreased GSDA activity. The higher activity of the process was observed, the greater activities of GDA, XO, PNP, GP and the lower activity of GSDA and ADA were. There were the enzymatic activity differences that depended on the degree of pathological process activity, clinical form, the magnitude of X-ray changes, and the degree of joint functional insufficiency.
Conclusion. The findings suggest that there may be PM disturbances in the immunocompetent cells. |
| first_indexed | 2024-12-21T20:23:47Z |
| format | Article |
| id | doaj.art-135fab20dfee4237bba421d5baaff2c6 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T20:23:47Z |
| publishDate | 2010-04-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-135fab20dfee4237bba421d5baaff2c62022-12-21T18:51:26Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422010-04-01824485227618The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritisAleksandr Borisovich ZborovskiyElena Eduardovna MozgovayaVladislav Fedorovich Martem'yanovOl'ga Petrovna Slyusar'Mikhail Yur'evich StazharovS A BedinaA B Zborovsky0E E Mozgovaya1V F Martemyanov2O P Slyusar3M Yu Stazharov4S A Bedina5Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesCity Clinical Hospital Twenty FiveResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesAim. To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS. Materials and methods. The serum activities of the PM enzymes: xanthine oxidase (XO), guanine deaminase (GDA), guanosine deaminase (GSDA), purine nucleoside phosphorylase (PNP), guanosine phosphorylase (GP), and adenosine deaminase (ADA) were determined in 55 patients (51 males and 4 females) aged 36.0 ± 1.4 years). A control group comprised 30 apparently age- and gender-matched healthy individuals, as in the study group. Results. On admission, the patients were found to have increased XO, GDA, PNP, and GD activities and decreased GSDA activity. The higher activity of the process was observed, the greater activities of GDA, XO, PNP, GP and the lower activity of GSDA and ADA were. There were the enzymatic activity differences that depended on the degree of pathological process activity, clinical form, the magnitude of X-ray changes, and the degree of joint functional insufficiency. Conclusion. The findings suggest that there may be PM disturbances in the immunocompetent cells.https://ter-arkhiv.ru/0040-3660/article/view/30591ankylosing spondyloarthritispurine metabolismxanthine oxidaseguanine deaminaseguanosine deaminasepurine nucleoside phosphorylaseguanosine phosphorylaseand adenosine deaminase |
| spellingShingle | Aleksandr Borisovich Zborovskiy Elena Eduardovna Mozgovaya Vladislav Fedorovich Martem'yanov Ol'ga Petrovna Slyusar' Mikhail Yur'evich Stazharov S A Bedina A B Zborovsky E E Mozgovaya V F Martemyanov O P Slyusar M Yu Stazharov S A Bedina The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis Терапевтический архив ankylosing spondyloarthritis purine metabolism xanthine oxidase guanine deaminase guanosine deaminase purine nucleoside phosphorylase guanosine phosphorylase and adenosine deaminase |
| title | The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis |
| title_full | The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis |
| title_fullStr | The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis |
| title_full_unstemmed | The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis |
| title_short | The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis |
| title_sort | clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis |
| topic | ankylosing spondyloarthritis purine metabolism xanthine oxidase guanine deaminase guanosine deaminase purine nucleoside phosphorylase guanosine phosphorylase and adenosine deaminase |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30591 |
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