Ascitic Senescent T Cells Are Linked to Chemoresistance in Patients With Advanced High-Grade Serous Ovarian Cancer

Ascitic Senescent T Cells Are Linked to Chemoresistance in Patients With Advanced High-Grade Serous Ovarian Cancer

Senescent T cells are reported to be increased in patients with cancer and are poor prognostic indicators. However, the distribution of senescent T cells and their correlation with clinical features in high-grade serous ovarian cancer (HGSOC) is unknown. We detected the percentage of senescent T cel...

Full description

Bibliographic Details
Main Authors:	Jie Zhang, Tianhui He, Zhongnan Yin, Chunliang Shang, Lixiang Xue, Hongyan Guo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Oncology
Subjects:	senescent T cells HGSOC ascites chemosensitivity biomarkers
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.864021/full

Similar Items

Senescent T cells: a potential biomarker and target for cancer therapy
by: Jie Zhang, et al.
Published: (2021-06-01)

Low Expression of Circular RNA hsa_circ_0078607 Predicts Poor Prognosis in High-Grade Serous Ovarian Cancer
by: Zhang N, et al.
Published: (2021-03-01)

Chemosensitization Effect of Seabuckthorn (<i>Hippophae rhamnoides</i> L.) Pulp Oil via Autophagy and Senescence in NSCLC Cells
by: Uyanga Batbold, et al.
Published: (2022-05-01)

Overview of Tumor Heterogeneity in High-Grade Serous Ovarian Cancers
by: Eros Azzalini, et al.
Published: (2023-10-01)

HDAC6 Degradation Inhibits the Growth of High-Grade Serous Ovarian Cancer Cells
by: Ahlam Ali, et al.
Published: (2020-12-01)

Next-generation sequencing shows the genomic features of ovarian clear cell cancer and compares the genetic architectures of high-grade serous ovarian cancer and clear cell carcinoma in ovarian and endometrial tissues
by: Meifu Gan, et al.
Published: (2023-01-01)

Primary Treatment Effects for High-Grade Serous Ovarian Carcinoma Evaluated by Changes in Serum Metabolites and Lipoproteins
by: Cecilie Fredvik Torkildsen, et al.
Published: (2023-03-01)

AKT Isoforms Interplay in High-Grade Serous Ovarian Cancer Prognosis and Characterization
by: Eros Azzalini, et al.
Published: (2022-01-01)

Compromise or not? A case report of successful treatment of pembrolizumab‐induced hepatitis in a patient with non‐small cell lung cancer with low‐dose methylprednisolone and bicyclol
by: Yan'e Liu, et al.
Published: (2020-07-01)

Activation of LXRɑ/β by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer
by: Soochi Kim, et al.
Published: (2018-12-01)

Biological and prognostic value of ETV5 in high-grade serous ovarian cancer
by: Lu Zhang, et al.
Published: (2021-11-01)

MicroRNA-625-3p improved proliferation and involved chemotherapy resistance via targeting PTEN in high grade ovarian serous carcinoma
by: Lili Zhong, et al.
Published: (2022-01-01)

Discovery of Prognostic Markers for Early-Stage High-Grade Serous Ovarian Cancer by Maldi-Imaging
by: Hagen Kulbe, et al.
Published: (2020-07-01)

Rescue of p53 functions by in vitro‐transcribed mRNA impedes the growth of high‐grade serous ovarian cancer
by: Monika Raab, et al.
Published: (2024-01-01)

Clinical Interest of Combining Transcriptomic and Genomic Signatures in High-Grade Serous Ovarian Cancer
by: Yann Kieffer, et al.
Published: (2020-03-01)

Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
by: Inga Hoffmann, et al.
Published: (2023-10-01)

What’s beyond BRCA Mutational Status in High Grade Serous Ovarian Cancer? The Impact of Hormone Receptor Expression in a Large BRCA-Profiled Ovarian Cancer Patient Series: A Retrospective Cohort Study
by: Emanuele Perrone, et al.
Published: (2022-09-01)

High EVI1 and PARP1 expression as favourable prognostic markers in high-grade serous ovarian carcinoma
by: Paul Jank, et al.
Published: (2023-07-01)

Patient-Specific Variables Determine the Extent of Cellular Senescence Biomarkers in Ovarian Tumors In Vivo
by: Paweł Uruski, et al.
Published: (2021-03-01)

A Comprehensive Analysis of Prognostic Indicators in Serous Ovarian Cancer Based on Leukocyte Migration and Immune Microenvironment
by: Junping Pan, et al.
Published: (2023-06-01)

A Rare Case of Deep Pelvic Endometriosis Presenting with Serous Ascites and Infertility
by: Türkan Gürsu, et al.
Published: (2016-02-01)

PTPN13 Participates in the Regulation of Epithelial–Mesenchymal Transition and Platinum Sensitivity in High-Grade Serous Ovarian Carcinoma Cells
by: Leticia Aptecar, et al.
Published: (2023-10-01)

Ascites Index – an attempt to objectify the assessment of ascites
by: Piotr Szkodziak, et al.
Published: (2018-06-01)

Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro
by: Paweł Uruski, et al.
Published: (2021-10-01)

Stress hormones are associated with inflammatory cytokines and attenuation of T-cell function in the ascites from patients with high grade serous ovarian cancer
by: Alexandra N. Aquino-Acevedo, et al.
Published: (2022-12-01)

The Role of Serum Ascites Albumin Gradient in the Differential Diagnosis of Ascites.
by: Hysni Dede, et al.
Published: (2022-01-01)

Chronic recurrent biliary ascites: An unusual scenario
by: Kutty Geeta, et al.
Published: (2014-01-01)

Evaluation of chemosensitivity prediction using quantitative dose–response curve classification for highly advanced/relapsed gastric cancer
by: Matsuo Teppei, et al.
Published: (2013-01-01)

Pancreatic ascites with 'inflammatory transudate'
by: M Rajendra Prasad, et al.
Published: (2019-01-01)

Modeling of senescence-related chemoresistance in ovarian cancer using data analysis and patient-derived organoids
by: Xintong Cai, et al.
Published: (2024-02-01)

Extracorporal modified ascitic fluid reinfusion in treatment of resistant ascites in liver cirrhosis
by: I. E. Onnintsev, et al.
Published: (2017-06-01)

Evaluation of electrolytes in the serum and ascitic fluid in broilers with Ascites syndrome
by: E.A Fathi Hafshajani, et al.
Published: (2012-11-01)

Characteristics of Extracellular Vesicles from a High-Grade Serous Ovarian Cancer Cell Line Derived from a Platinum-Resistant Patient as a Potential Tool for Aiding the Prediction of Responses to Chemotherapy
by: Katarina Černe, et al.
Published: (2023-06-01)

Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types
by: Masaki Kobayashi, et al.
Published: (2018-09-01)

Utility of ultrasound in diagnosis of the source of ascites
by: Saberi H, et al.
Published: (1999-07-01)

The Comparison of Total Protein of Ascites Fluid with Serum Ascites Albumin Gradient as Criterion in the Differential Diagnosis of Ascites
by: Mostafa Ansari, et al.
Published: (1999-09-01)

Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 Inhibitors
by: Khayal Gasimli, et al.
Published: (2023-12-01)

ZIP4 Is a Novel Cancer Stem Cell Marker in High-Grade Serous Ovarian Cancer
by: Qipeng Fan, et al.
Published: (2020-12-01)

High expression of fibroblast activation protein (FAP) predicts poor outcome in high-grade serous ovarian cancer
by: Min Li, et al.
Published: (2020-10-01)

CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma
by: Katrin Kleinmanns, et al.
Published: (2020-06-01)