Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points
Dental pulp tissue can be damaged by a range of irritants, however, if the irritation is removed and/or the tooth is adequately restored, pulp regeneration is possible (Mjör and Tronstad, 1974 [1]). At present, dental restorative materials limit healing by impairing mineralization and repair process...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Genomics Data |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213596015001579 |
| _version_ | 1818598182016253952 |
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| author | Henry F. Duncan Anthony J. Smith Garry J.P. Fleming Gary P. Moran Paul R. Cooper |
| author_facet | Henry F. Duncan Anthony J. Smith Garry J.P. Fleming Gary P. Moran Paul R. Cooper |
| author_sort | Henry F. Duncan |
| collection | DOAJ |
| description | Dental pulp tissue can be damaged by a range of irritants, however, if the irritation is removed and/or the tooth is adequately restored, pulp regeneration is possible (Mjör and Tronstad, 1974 [1]). At present, dental restorative materials limit healing by impairing mineralization and repair processes and as a result new biologically-based materials are being developed (Ferracane et al., 2010 [2]). Previous studies have highlighted the benefit of epigenetic modification by histone deacetylase inhibitor (HDACi) application to dental pulp cells (DPCs), which induces changes to chromatin architecture, promoting gene expression and cellular-reparative events (Duncan et al., 2013 [3]; Paino et al., 2014 [4]). In this study a genome-wide transcription profiling in epigenetically-modified mineralizing primary DPC cultures was performed, at relatively early and late time-points, to identify differentially regulated transcripts that may provide novel therapeutic targets for use in restorative dentistry. Here we provide detailed methods and analysis on these microarray data which has been deposited in Gene Expression Omnibus (GEO): GSE67175. |
| first_indexed | 2024-12-16T11:59:38Z |
| format | Article |
| id | doaj.art-13632a17b2c243e1867074b774e9b3cc |
| institution | Directory Open Access Journal |
| issn | 2213-5960 |
| language | English |
| last_indexed | 2024-12-16T11:59:38Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Genomics Data |
| spelling | doaj.art-13632a17b2c243e1867074b774e9b3cc2022-12-21T22:32:29ZengElsevierGenomics Data2213-59602015-09-015C39139310.1016/j.gdata.2015.07.013Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time pointsHenry F. Duncan0Anthony J. Smith1Garry J.P. Fleming2Gary P. Moran3Paul R. Cooper4Division of Restorative Dentistry & Periodontology, Dublin Dental University Hospital, Trinity College Dublin, Lincoln Place, Dublin 2, IrelandOral Biology, School of Dentistry, University of Birmingham, Birmingham B4 6NN, UKMaterial Science Unit, Dublin Dental University Hospital, Trinity College Dublin, IrelandDivision of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, IrelandOral Biology, School of Dentistry, University of Birmingham, Birmingham B4 6NN, UKDental pulp tissue can be damaged by a range of irritants, however, if the irritation is removed and/or the tooth is adequately restored, pulp regeneration is possible (Mjör and Tronstad, 1974 [1]). At present, dental restorative materials limit healing by impairing mineralization and repair processes and as a result new biologically-based materials are being developed (Ferracane et al., 2010 [2]). Previous studies have highlighted the benefit of epigenetic modification by histone deacetylase inhibitor (HDACi) application to dental pulp cells (DPCs), which induces changes to chromatin architecture, promoting gene expression and cellular-reparative events (Duncan et al., 2013 [3]; Paino et al., 2014 [4]). In this study a genome-wide transcription profiling in epigenetically-modified mineralizing primary DPC cultures was performed, at relatively early and late time-points, to identify differentially regulated transcripts that may provide novel therapeutic targets for use in restorative dentistry. Here we provide detailed methods and analysis on these microarray data which has been deposited in Gene Expression Omnibus (GEO): GSE67175.http://www.sciencedirect.com/science/article/pii/S2213596015001579 |
| spellingShingle | Henry F. Duncan Anthony J. Smith Garry J.P. Fleming Gary P. Moran Paul R. Cooper Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points Genomics Data |
| title | Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points |
| title_full | Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points |
| title_fullStr | Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points |
| title_full_unstemmed | Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points |
| title_short | Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points |
| title_sort | transcriptional profiling of suberoylanilide hydroxamic acid saha regulated genes in mineralizing dental pulp cells at early and late time points |
| url | http://www.sciencedirect.com/science/article/pii/S2213596015001579 |
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