Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal application
The ACR/EULAR classification criteria for systemic sclerosis (SSc) entail three autoantibodies: anti-centromere antibodies (ACA), anti-topoisomerase I antibodies (ATA), and anti-RNA-polymerase III antibodies (ARA). The importance of ACA and ATA in the classification criteria is evidence based, but t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Journal of Translational Autoimmunity |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909022000028 |
| _version_ | 1811199496982364160 |
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| author | Jan Damoiseaux Judith Potjewijd Ruben L. Smeets Carolien Bonroy |
| author_facet | Jan Damoiseaux Judith Potjewijd Ruben L. Smeets Carolien Bonroy |
| author_sort | Jan Damoiseaux |
| collection | DOAJ |
| description | The ACR/EULAR classification criteria for systemic sclerosis (SSc) entail three autoantibodies: anti-centromere antibodies (ACA), anti-topoisomerase I antibodies (ATA), and anti-RNA-polymerase III antibodies (ARA). The importance of ACA and ATA in the classification criteria is evidence based, but the diagnostic value is overestimated by clinicians. Fortunately, these autoantibodies are characterized by good agreement between different immuno-assays. Inclusion of ARA, however, is based on limited evidence and is related to limited agreement between different immuno-assays. Harmonization of immuno-assays in terms of interpretation based on likelihood ratio's may improve future classification criteria for SSc and this needs to be achieved by close collaboration between clinicians, laboratory specialists and the diagnostic industry. |
| first_indexed | 2024-04-12T01:49:02Z |
| format | Article |
| id | doaj.art-1363b5df3ff04f34a53686bb495fedaf |
| institution | Directory Open Access Journal |
| issn | 2589-9090 |
| language | English |
| last_indexed | 2024-04-12T01:49:02Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj.art-1363b5df3ff04f34a53686bb495fedaf2022-12-22T03:52:59ZengElsevierJournal of Translational Autoimmunity2589-90902022-01-015100141Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal applicationJan Damoiseaux0Judith Potjewijd1Ruben L. Smeets2Carolien Bonroy3Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands; Corresponding author.Department of Internal Medicine, Division Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, the NetherlandsDepartment of Laboratory Medicine, Radboudumc Laboratory for Diagnostics, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Laboratory Medicine—Medical Immunology, Radboud University Medical Center, Nijmegen, the NetherlandsDepartment of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium; Department of Diagnostic Sciences, Ghent University, Ghent, BelgiumThe ACR/EULAR classification criteria for systemic sclerosis (SSc) entail three autoantibodies: anti-centromere antibodies (ACA), anti-topoisomerase I antibodies (ATA), and anti-RNA-polymerase III antibodies (ARA). The importance of ACA and ATA in the classification criteria is evidence based, but the diagnostic value is overestimated by clinicians. Fortunately, these autoantibodies are characterized by good agreement between different immuno-assays. Inclusion of ARA, however, is based on limited evidence and is related to limited agreement between different immuno-assays. Harmonization of immuno-assays in terms of interpretation based on likelihood ratio's may improve future classification criteria for SSc and this needs to be achieved by close collaboration between clinicians, laboratory specialists and the diagnostic industry.http://www.sciencedirect.com/science/article/pii/S2589909022000028Systemic sclerosisClassificationAutoantibodiesHarmonization |
| spellingShingle | Jan Damoiseaux Judith Potjewijd Ruben L. Smeets Carolien Bonroy Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal application Journal of Translational Autoimmunity Systemic sclerosis Classification Autoantibodies Harmonization |
| title | Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal application |
| title_full | Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal application |
| title_fullStr | Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal application |
| title_full_unstemmed | Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal application |
| title_short | Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal application |
| title_sort | autoantibodies in the disease criteria for systemic sclerosis the need for specification for optimal application |
| topic | Systemic sclerosis Classification Autoantibodies Harmonization |
| url | http://www.sciencedirect.com/science/article/pii/S2589909022000028 |
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