Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements
Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternativ...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/6/1567 |
| _version_ | 1797470503432093696 |
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| author | Annemarie Lippert Bertold Renner |
| author_facet | Annemarie Lippert Bertold Renner |
| author_sort | Annemarie Lippert |
| collection | DOAJ |
| description | Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternative treatment, but also combined with conventional drugs. These combinations deserve careful contemplation, as the complex mixtures of bioactive substances in plants show a potential for interactions. Induction of CYP enzymes and pGP by St John’s wort may be the most famous example, but there is much more to consider. In this review, we shed light on what is known about the interactions between botanicals and drugs, in order to make practitioners aware of potential drug-related problems. The main focus of the article is the treatment of inflammatory diseases, accompanied by plant preparations used in Europe. Several of the drugs we discuss here, as basal medication in chronic inflammatory diseases (e.g., methotrexate, janus kinase inhibitors), are also used as oral tumor therapeutics. |
| first_indexed | 2024-03-09T19:37:12Z |
| format | Article |
| id | doaj.art-13676eda4223412a97d4a0740dbe0f8e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T19:37:12Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-13676eda4223412a97d4a0740dbe0f8e2023-11-24T01:48:27ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01116156710.3390/jcm11061567Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal SupplementsAnnemarie Lippert0Bertold Renner1Institute of Clinical Pharmacology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01069 Dresden, GermanyInstitute of Clinical Pharmacology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01069 Dresden, GermanyMany people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternative treatment, but also combined with conventional drugs. These combinations deserve careful contemplation, as the complex mixtures of bioactive substances in plants show a potential for interactions. Induction of CYP enzymes and pGP by St John’s wort may be the most famous example, but there is much more to consider. In this review, we shed light on what is known about the interactions between botanicals and drugs, in order to make practitioners aware of potential drug-related problems. The main focus of the article is the treatment of inflammatory diseases, accompanied by plant preparations used in Europe. Several of the drugs we discuss here, as basal medication in chronic inflammatory diseases (e.g., methotrexate, janus kinase inhibitors), are also used as oral tumor therapeutics.https://www.mdpi.com/2077-0383/11/6/1567rheumatoid arthritisinflammatory bowel diseaseherbal medical productscomplementary medicinegreen teaginseng |
| spellingShingle | Annemarie Lippert Bertold Renner Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements Journal of Clinical Medicine rheumatoid arthritis inflammatory bowel disease herbal medical products complementary medicine green tea ginseng |
| title | Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements |
| title_full | Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements |
| title_fullStr | Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements |
| title_full_unstemmed | Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements |
| title_short | Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements |
| title_sort | herb drug interaction in inflammatory diseases review of phytomedicine and herbal supplements |
| topic | rheumatoid arthritis inflammatory bowel disease herbal medical products complementary medicine green tea ginseng |
| url | https://www.mdpi.com/2077-0383/11/6/1567 |
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