A Mouse Model of Chronic West Nile Virus Disease.
Infection with West Nile virus (WNV) leads to a range of disease outcomes, including chronic infection, though lack of a robust mouse model of chronic WNV infection has precluded identification of the immune events contributing to persistent infection. Using the Collaborative Cross, a population of...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-11-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC5091767?pdf=render |
| _version_ | 1818132477071327232 |
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| author | Jessica B Graham Jessica L Swarts Courtney Wilkins Sunil Thomas Richard Green Aimee Sekine Kathleen M Voss Renee C Ireton Michael Mooney Gabrielle Choonoo Darla R Miller Piper M Treuting Fernando Pardo Manuel de Villena Martin T Ferris Shannon McWeeney Michael Gale Jennifer M Lund |
| author_facet | Jessica B Graham Jessica L Swarts Courtney Wilkins Sunil Thomas Richard Green Aimee Sekine Kathleen M Voss Renee C Ireton Michael Mooney Gabrielle Choonoo Darla R Miller Piper M Treuting Fernando Pardo Manuel de Villena Martin T Ferris Shannon McWeeney Michael Gale Jennifer M Lund |
| author_sort | Jessica B Graham |
| collection | DOAJ |
| description | Infection with West Nile virus (WNV) leads to a range of disease outcomes, including chronic infection, though lack of a robust mouse model of chronic WNV infection has precluded identification of the immune events contributing to persistent infection. Using the Collaborative Cross, a population of recombinant inbred mouse strains with high levels of standing genetic variation, we have identified a mouse model of persistent WNV disease, with persistence of viral loads within the brain. Compared to lines exhibiting no disease or marked disease, the F1 cross CC(032x013)F1 displays a strong immunoregulatory signature upon infection that correlates with restraint of the WNV-directed cytolytic response. We hypothesize that this regulatory T cell response sufficiently restrains the immune response such that a chronic infection can be maintained in the CNS. Use of this new mouse model of chronic neuroinvasive virus will be critical in developing improved strategies to prevent prolonged disease in humans. |
| first_indexed | 2024-12-11T08:37:27Z |
| format | Article |
| id | doaj.art-1368135a2e7e452780f93435ca1dd3a6 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-11T08:37:27Z |
| publishDate | 2016-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-1368135a2e7e452780f93435ca1dd3a62022-12-22T01:14:20ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742016-11-011211e100599610.1371/journal.ppat.1005996A Mouse Model of Chronic West Nile Virus Disease.Jessica B GrahamJessica L SwartsCourtney WilkinsSunil ThomasRichard GreenAimee SekineKathleen M VossRenee C IretonMichael MooneyGabrielle ChoonooDarla R MillerPiper M TreutingFernando Pardo Manuel de VillenaMartin T FerrisShannon McWeeneyMichael GaleJennifer M LundInfection with West Nile virus (WNV) leads to a range of disease outcomes, including chronic infection, though lack of a robust mouse model of chronic WNV infection has precluded identification of the immune events contributing to persistent infection. Using the Collaborative Cross, a population of recombinant inbred mouse strains with high levels of standing genetic variation, we have identified a mouse model of persistent WNV disease, with persistence of viral loads within the brain. Compared to lines exhibiting no disease or marked disease, the F1 cross CC(032x013)F1 displays a strong immunoregulatory signature upon infection that correlates with restraint of the WNV-directed cytolytic response. We hypothesize that this regulatory T cell response sufficiently restrains the immune response such that a chronic infection can be maintained in the CNS. Use of this new mouse model of chronic neuroinvasive virus will be critical in developing improved strategies to prevent prolonged disease in humans.http://europepmc.org/articles/PMC5091767?pdf=render |
| spellingShingle | Jessica B Graham Jessica L Swarts Courtney Wilkins Sunil Thomas Richard Green Aimee Sekine Kathleen M Voss Renee C Ireton Michael Mooney Gabrielle Choonoo Darla R Miller Piper M Treuting Fernando Pardo Manuel de Villena Martin T Ferris Shannon McWeeney Michael Gale Jennifer M Lund A Mouse Model of Chronic West Nile Virus Disease. PLoS Pathogens |
| title | A Mouse Model of Chronic West Nile Virus Disease. |
| title_full | A Mouse Model of Chronic West Nile Virus Disease. |
| title_fullStr | A Mouse Model of Chronic West Nile Virus Disease. |
| title_full_unstemmed | A Mouse Model of Chronic West Nile Virus Disease. |
| title_short | A Mouse Model of Chronic West Nile Virus Disease. |
| title_sort | mouse model of chronic west nile virus disease |
| url | http://europepmc.org/articles/PMC5091767?pdf=render |
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