Structural Insights of Three 2,4-Disubstituted Dihydropyrimidine-5-carbonitriles as Potential Dihydrofolate Reductase Inhibitors

Structural Insights of Three 2,4-Disubstituted Dihydropyrimidine-5-carbonitriles as Potential Dihydrofolate Reductase Inhibitors

In this report, we describe the structural characterization of three 2,4-disubstituted-dihydropyrimidine-5-carbonitrile derivatives, namely 2-{[(4-nitrophenyl)methyl]sulfanyl}-6-oxo-4-propyl-1,6-dihydropyrimidine-5-carbonitrile <b>1</b>, 4-(2-methylpropyl)-2-{[(4-nitrophenyl)methyl]sulfa...

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Bibliographic Details
Main Authors: Lamya H. Al-Wahaibi, Althaf Shaik, Mohammed A. Elmorsy, Mohammed S. M. Abdelbaky, Santiago Garcia-Granda, Subbiah Thamotharan, Vijay Thiruvenkatam, Ali A. El-Emam
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
pyrimidine-5-carbonitriles
dihydrofolate reductase
crystal structure
DFT
Hirshfeld surface analysis
Online Access:https://www.mdpi.com/1420-3049/26/11/3286

Internet

https://www.mdpi.com/1420-3049/26/11/3286

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