Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers
The rate of post-transplant mothers who breastfeed while on immunosuppression is progressively increasing. Data on breastfeeding while on cyclosporine-based regimens are limited. Therefore, we assessed the amount of cyclosporine and its metabolites that might be ingested by a breastfed infant by mea...
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2713 |
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| author | Bożena Kociszewska-Najman Natalia Mazanowska Beata Borek-Dzięcioł Leszek Pączek Emilia Samborowska Monika Szpotańska-Sikorska Bronisława Pietrzak Michał Dadlez Mirosław Wielgoś |
| author_facet | Bożena Kociszewska-Najman Natalia Mazanowska Beata Borek-Dzięcioł Leszek Pączek Emilia Samborowska Monika Szpotańska-Sikorska Bronisława Pietrzak Michał Dadlez Mirosław Wielgoś |
| author_sort | Bożena Kociszewska-Najman |
| collection | DOAJ |
| description | The rate of post-transplant mothers who breastfeed while on immunosuppression is progressively increasing. Data on breastfeeding while on cyclosporine-based regimens are limited. Therefore, we assessed the amount of cyclosporine and its metabolites that might be ingested by a breastfed infant by measuring the concentration of cyclosporine and its metabolites in the colostrum of seven post-transplant mothers. The mean concentration of cyclosporine in the colostrum was 22.40 ± 9.43 mcg/L, and the estimated mean daily dose of the drug was 1049.22 ± 397.41 ng/kg/24 h. Only three metabolites (AM1, DHCsA, and THCsA) had mean colostrum amounts comparable to or higher than cyclosporine itself, with the daily doses being 468.51 ± 80.37, 2757.79 ± 1926.11, and 1044.76 ± 948.56 ng/kg/24 h, respectively. Our results indicate a low transfer of cyclosporine and its metabolites into the colostrum in the first two days postpartum and confirm the emerging change to the policy on breastfeeding among post-transplant mothers. A full assessment of the safety of immunosuppressant exposure via breastmilk will require further studies with long-term follow-ups of breastfed children. |
| first_indexed | 2024-03-10T16:33:35Z |
| format | Article |
| id | doaj.art-136e36b29a33485084e79f7f6e050f57 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:33:35Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-136e36b29a33485084e79f7f6e050f572023-11-20T12:39:37ZengMDPI AGNutrients2072-66432020-09-01129271310.3390/nu12092713Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant MothersBożena Kociszewska-Najman0Natalia Mazanowska1Beata Borek-Dzięcioł2Leszek Pączek3Emilia Samborowska4Monika Szpotańska-Sikorska5Bronisława Pietrzak6Michał Dadlez7Mirosław Wielgoś8Department of Neonatology, Medical University of Warsaw, 02-091 Warsaw, PolandFirst Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, PolandDepartment of Neonatology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Immunology, Transplant Medicine and Internal Diseases, Transplantation Institute, Medical University of Warsaw, 02-014 Warsaw, PolandMass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, PolandFirst Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, PolandFirst Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, PolandMass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, PolandFirst Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, PolandThe rate of post-transplant mothers who breastfeed while on immunosuppression is progressively increasing. Data on breastfeeding while on cyclosporine-based regimens are limited. Therefore, we assessed the amount of cyclosporine and its metabolites that might be ingested by a breastfed infant by measuring the concentration of cyclosporine and its metabolites in the colostrum of seven post-transplant mothers. The mean concentration of cyclosporine in the colostrum was 22.40 ± 9.43 mcg/L, and the estimated mean daily dose of the drug was 1049.22 ± 397.41 ng/kg/24 h. Only three metabolites (AM1, DHCsA, and THCsA) had mean colostrum amounts comparable to or higher than cyclosporine itself, with the daily doses being 468.51 ± 80.37, 2757.79 ± 1926.11, and 1044.76 ± 948.56 ng/kg/24 h, respectively. Our results indicate a low transfer of cyclosporine and its metabolites into the colostrum in the first two days postpartum and confirm the emerging change to the policy on breastfeeding among post-transplant mothers. A full assessment of the safety of immunosuppressant exposure via breastmilk will require further studies with long-term follow-ups of breastfed children.https://www.mdpi.com/2072-6643/12/9/2713breastfeedingimmunosuppressioncyclosporine Atransplantlactation |
| spellingShingle | Bożena Kociszewska-Najman Natalia Mazanowska Beata Borek-Dzięcioł Leszek Pączek Emilia Samborowska Monika Szpotańska-Sikorska Bronisława Pietrzak Michał Dadlez Mirosław Wielgoś Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers Nutrients breastfeeding immunosuppression cyclosporine A transplant lactation |
| title | Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers |
| title_full | Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers |
| title_fullStr | Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers |
| title_full_unstemmed | Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers |
| title_short | Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers |
| title_sort | low content of cyclosporine a and its metabolites in the colostrum of post transplant mothers |
| topic | breastfeeding immunosuppression cyclosporine A transplant lactation |
| url | https://www.mdpi.com/2072-6643/12/9/2713 |
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