The Effect of Vascular Risk Factors on the Efficacy of Rivastigmine Patch and Capsule Treatment in Alzheimer’s Disease
Background: Vascular risk factors (VRF) may influence response to rivastigmine in Alzheimer’s disease (AD). Methods: AD patients who participated in a randomized, double-blind, placebo-controlled trial of rivastigmine patch and capsule treatment were stratified by baseline VRF status. Treatment resp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2011-06-01
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| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/328745 |
| _version_ | 1818596523576918016 |
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| author | M.R. Farlow P.M. Doraiswamy X. Meng K. Cooke M. Somogyi |
| author_facet | M.R. Farlow P.M. Doraiswamy X. Meng K. Cooke M. Somogyi |
| author_sort | M.R. Farlow |
| collection | DOAJ |
| description | Background: Vascular risk factors (VRF) may influence response to rivastigmine in Alzheimer’s disease (AD). Methods: AD patients who participated in a randomized, double-blind, placebo-controlled trial of rivastigmine patch and capsule treatment were stratified by baseline VRF status. Treatment response was evaluated using the AD Assessment Scale-cognitive subscale (ADAS-cog), AD Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) and the AD Cooperative Study-Activities of Daily Living (ADCS-ADL) scale. Results: ADAS-cog scores significantly improved in all rivastigmine-treated patients (p Conclusion: VRF may influence AD progression and response to rivastigmine. |
| first_indexed | 2024-12-16T11:33:16Z |
| format | Article |
| id | doaj.art-13715cbc0c514a0c92bbfbaad4a54c64 |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-12-16T11:33:16Z |
| publishDate | 2011-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-13715cbc0c514a0c92bbfbaad4a54c642022-12-21T22:33:11ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642011-06-011115016210.1159/000328745328745The Effect of Vascular Risk Factors on the Efficacy of Rivastigmine Patch and Capsule Treatment in Alzheimer’s DiseaseM.R. FarlowP.M. DoraiswamyX. MengK. CookeM. SomogyiBackground: Vascular risk factors (VRF) may influence response to rivastigmine in Alzheimer’s disease (AD). Methods: AD patients who participated in a randomized, double-blind, placebo-controlled trial of rivastigmine patch and capsule treatment were stratified by baseline VRF status. Treatment response was evaluated using the AD Assessment Scale-cognitive subscale (ADAS-cog), AD Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) and the AD Cooperative Study-Activities of Daily Living (ADCS-ADL) scale. Results: ADAS-cog scores significantly improved in all rivastigmine-treated patients (p Conclusion: VRF may influence AD progression and response to rivastigmine.http://www.karger.com/Article/FullText/328745Alzheimerߣs diseaseEfficacyRivastigmineTransdermal patchVascular risk factors |
| spellingShingle | M.R. Farlow P.M. Doraiswamy X. Meng K. Cooke M. Somogyi The Effect of Vascular Risk Factors on the Efficacy of Rivastigmine Patch and Capsule Treatment in Alzheimer’s Disease Dementia and Geriatric Cognitive Disorders Extra Alzheimerߣs disease Efficacy Rivastigmine Transdermal patch Vascular risk factors |
| title | The Effect of Vascular Risk Factors on the Efficacy of Rivastigmine Patch and Capsule Treatment in Alzheimer’s Disease |
| title_full | The Effect of Vascular Risk Factors on the Efficacy of Rivastigmine Patch and Capsule Treatment in Alzheimer’s Disease |
| title_fullStr | The Effect of Vascular Risk Factors on the Efficacy of Rivastigmine Patch and Capsule Treatment in Alzheimer’s Disease |
| title_full_unstemmed | The Effect of Vascular Risk Factors on the Efficacy of Rivastigmine Patch and Capsule Treatment in Alzheimer’s Disease |
| title_short | The Effect of Vascular Risk Factors on the Efficacy of Rivastigmine Patch and Capsule Treatment in Alzheimer’s Disease |
| title_sort | effect of vascular risk factors on the efficacy of rivastigmine patch and capsule treatment in alzheimer s disease |
| topic | Alzheimerߣs disease Efficacy Rivastigmine Transdermal patch Vascular risk factors |
| url | http://www.karger.com/Article/FullText/328745 |
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