Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis
Abstract Human African Trypanosomiasis (HAT) is a parasitic disease originating in sub-Saharan Africa. There is limited information about the changes in the blood brain barrier (BBB) during this infection. This study is the first to apply diffusion weighted ASL (DWASL) to examine changes in BBB impa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34665-z |
| _version_ | 1797811468440174592 |
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| author | Samantha Paterson Antoine Vallatos Jean Rodgers William M. Holmes |
| author_facet | Samantha Paterson Antoine Vallatos Jean Rodgers William M. Holmes |
| author_sort | Samantha Paterson |
| collection | DOAJ |
| description | Abstract Human African Trypanosomiasis (HAT) is a parasitic disease originating in sub-Saharan Africa. There is limited information about the changes in the blood brain barrier (BBB) during this infection. This study is the first to apply diffusion weighted ASL (DWASL) to examine changes in BBB impairment. No significant changes in water exchange across the BBB were found during the infection, even when a loss of barrier integrity was seen using Contrast Enhanced MRI (Gd-DTPA) during the late stage of the disease. Furthermore, using multiple boli ASL (mbASL), changes in cerebral blood flow (CBF) were found during the course of infection. Overall, this study highlights the need for further study of the BBB during HAT infection to understand the complex mechanisms behind impairment. |
| first_indexed | 2024-03-13T07:23:58Z |
| format | Article |
| id | doaj.art-13719810abe64c25913e1c6cb32c55a8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T07:23:58Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-13719810abe64c25913e1c6cb32c55a82023-06-04T11:29:14ZengNature PortfolioScientific Reports2045-23222023-05-011311910.1038/s41598-023-34665-zApplication of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasisSamantha Paterson0Antoine Vallatos1Jean Rodgers2William M. Holmes3Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of LeedsGlasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of GlasgowInstitute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of GlasgowGlasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of GlasgowAbstract Human African Trypanosomiasis (HAT) is a parasitic disease originating in sub-Saharan Africa. There is limited information about the changes in the blood brain barrier (BBB) during this infection. This study is the first to apply diffusion weighted ASL (DWASL) to examine changes in BBB impairment. No significant changes in water exchange across the BBB were found during the infection, even when a loss of barrier integrity was seen using Contrast Enhanced MRI (Gd-DTPA) during the late stage of the disease. Furthermore, using multiple boli ASL (mbASL), changes in cerebral blood flow (CBF) were found during the course of infection. Overall, this study highlights the need for further study of the BBB during HAT infection to understand the complex mechanisms behind impairment.https://doi.org/10.1038/s41598-023-34665-z |
| spellingShingle | Samantha Paterson Antoine Vallatos Jean Rodgers William M. Holmes Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis Scientific Reports |
| title | Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis |
| title_full | Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis |
| title_fullStr | Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis |
| title_full_unstemmed | Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis |
| title_short | Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis |
| title_sort | application of diffusion weighted multiple boli asl to a murine model of human african trypanosomiasis |
| url | https://doi.org/10.1038/s41598-023-34665-z |
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