Application of an Endothelial Cell Culture Assay for the Detection of Neutralizing Anti-Clostridium Perfringens Beta-Toxin Antibodies in a Porcine Vaccination Trial

Application of an Endothelial Cell Culture Assay for the Detection of Neutralizing Anti-Clostridium Perfringens Beta-Toxin Antibodies in a Porcine Vaccination Trial

Background: Beta-toxin (CPB) is the major virulence factor of <i>Clostridium perfringens</i> type C, causing hemorrhagic enteritis in newborn pigs but also other animals and humans. Vaccines containing inactivated CPB are known to induce protective antibody titers in sow colostrum and ne...

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Bibliographic Details
Main Authors: Olivia K. Richard, Sven Springer, Jacqueline Finzel, Tobias Theuß, Marianne Wyder, Beatriz Vidondo, Horst Posthaus
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Toxins
Subjects:
necrotizing enteritis
<i>C. perfringens</i> type C
beta-toxin
neutralizing antibodies
cell culture assay
primary porcine endothelial cell
Online Access:https://www.mdpi.com/2072-6651/11/4/225

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