De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastases
Large-cell neuroendocrine carcinoma (LCNEC) is a rare neuroendocrine prostatic malignancy. It usually arises after androgen deprivation therapy (ADT), while de novo cases are even more infrequent, with only six cases described. The patient was a 78-year-old man with no history of ADT who presented w...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-12-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM22-0301.xml |
| _version_ | 1797980551668301824 |
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| author | Evangelos Karvounis Ioannis Zoupas Dimitra Bantouna Rodis D Paparodis Roxani Efthymiadou Christina Ioakimidou Christos Panopoulos |
| author_facet | Evangelos Karvounis Ioannis Zoupas Dimitra Bantouna Rodis D Paparodis Roxani Efthymiadou Christina Ioakimidou Christos Panopoulos |
| author_sort | Evangelos Karvounis |
| collection | DOAJ |
| description | Large-cell neuroendocrine carcinoma (LCNEC) is a rare neuroendocrine prostatic malignancy. It usually arises after androgen deprivation therapy (ADT), while de novo cases are even more infrequent, with only six cases described. The patient was a 78-year-old man with no history of ADT who presented with cervical lymphadenopathy. Diagnostic approaches included PET/CT, MRI, CT scans, ultrasonography, biopsies, and cytological and immunohistochemical evaluations. Results showed a poorly differentiated carcinoma in the thyroid gland accompanied by cervical lymph node enlargement. Thyroid surgery revealed LCNEC metastasis to the thyroid gland. Additional metastases were identified in both the adrenal glands. Despite appropriate treatment, the patient died of the disease. De novo LCNEC of the prostate is a rare, highly aggressive tumor with a poor prognosis. It is resistant to most therapeutic agents, has a high metastatic potential, and is usually diagnosed at an advanced stage. Further studies are required to characterize this tumor. |
| first_indexed | 2024-04-11T05:57:11Z |
| format | Article |
| id | doaj.art-137219e61cf64ac8955acb7027799e81 |
| institution | Directory Open Access Journal |
| issn | 2052-0573 |
| language | English |
| last_indexed | 2024-04-11T05:57:11Z |
| publishDate | 2022-12-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-137219e61cf64ac8955acb7027799e812022-12-22T04:41:52ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732022-12-01111510.1530/EDM-22-0301De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastasesEvangelos Karvounis0Ioannis Zoupas1Dimitra Bantouna2Rodis D Paparodis3Roxani Efthymiadou4Christina Ioakimidou5Christos Panopoulos6Department of Endocrine Surgery, ‘Euroclinic’ Hospital, Athens, GreeceDepartment of Endocrine Surgery, ‘Euroclinic’ Hospital, Athens, GreecePrivate Practice, Patras, GreecePrivate Practice, Patras, Greece; Center for Diabetes and Endocrine Research, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USAPET-CT Department, Hygeia Hospital, Athens, GreeceDepartment of PathologyDepartment of Medical Oncology, ‘Euroclinic’ Hospital, Athens, GreeceLarge-cell neuroendocrine carcinoma (LCNEC) is a rare neuroendocrine prostatic malignancy. It usually arises after androgen deprivation therapy (ADT), while de novo cases are even more infrequent, with only six cases described. The patient was a 78-year-old man with no history of ADT who presented with cervical lymphadenopathy. Diagnostic approaches included PET/CT, MRI, CT scans, ultrasonography, biopsies, and cytological and immunohistochemical evaluations. Results showed a poorly differentiated carcinoma in the thyroid gland accompanied by cervical lymph node enlargement. Thyroid surgery revealed LCNEC metastasis to the thyroid gland. Additional metastases were identified in both the adrenal glands. Despite appropriate treatment, the patient died of the disease. De novo LCNEC of the prostate is a rare, highly aggressive tumor with a poor prognosis. It is resistant to most therapeutic agents, has a high metastatic potential, and is usually diagnosed at an advanced stage. Further studies are required to characterize this tumor.https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM22-0301.xml |
| spellingShingle | Evangelos Karvounis Ioannis Zoupas Dimitra Bantouna Rodis D Paparodis Roxani Efthymiadou Christina Ioakimidou Christos Panopoulos De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastases Endocrinology, Diabetes & Metabolism Case Reports |
| title | De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastases |
| title_full | De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastases |
| title_fullStr | De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastases |
| title_full_unstemmed | De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastases |
| title_short | De novo purely prostatic large-cell neuroendocrine carcinoma with thyroid and adrenal metastases |
| title_sort | de novo purely prostatic large cell neuroendocrine carcinoma with thyroid and adrenal metastases |
| url | https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM22-0301.xml |
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