Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling

Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling

Abstract Background The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend healthy lifespan in diverse animal species, but with trade-offs includ...

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Bibliographic Details
Main Authors: Nathaniel S. Woodling, Arjunan Rajasingam, Lucy J. Minkley, Alberto Rizzo, Linda Partridge
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Biology
Subjects:
Ageing
Astrocytes
Glia
Insulin signalling
Lifespan
Online Access:http://link.springer.com/article/10.1186/s12915-020-00854-9

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