Cancer-associated fibroblast infiltration in osteosarcoma: the discrepancy in subtypes pathways and immunosuppression

Introduction: Osteosarcoma (OS), the primary malignant bone tumor, has a low survival rate for recurrent patients. Latest reports indicated that cancer-associated fibroblasts (CAFs) were the main component of tumor microenvironment, and would generate a variable role in the progression of tumors. Ho...

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Bibliographic Details
Main Authors: Zhang Zhihao, Ju Cheng, Zuo Xiaoshuang, Ma Yangguang, Wu Tingyu, Yang Yongyong, Yao Zhou, Zhou Jie, Zhang Tao, Hu Xueyu, Wang Zhe
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1136960/full