Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

Abstract Background The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement cascade is a complex immune process with many bioactive end-products, including mediators of inflammation. Complement cas...

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Bibliographic Details
Main Authors: Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongtian S. Yang, Jocelyn M. Thomas, Nicole E. Foxworth, Simon W. M. John, Gareth R. Howell
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Neuroinflammation
Subjects:
Glaucoma
Complement
Anaphylatoxin
Microglia
Monocytes
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s12974-020-02011-z

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