Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome
ObjectivesPolycystic ovary syndrome (PCOS) is one of the most common endocrinopathy disorders in premenopausal women, which is characterized by hyperandrogenemia, anovulation, and polycystic ovarian morphology (PCOM). Time-restricted feeding (TRF) is a new intermittent restriction dietary pattern, w...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1057376/full |
| _version_ | 1797980787644039168 |
|---|---|
| author | Yan Han Baiwei Lin Wenjing Lu Xu Wang Xu Wang Wenshuai Tang Xinge Tao Han Cai Chunmei He Changqin Liu Changqin Liu |
| author_facet | Yan Han Baiwei Lin Wenjing Lu Xu Wang Xu Wang Wenshuai Tang Xinge Tao Han Cai Chunmei He Changqin Liu Changqin Liu |
| author_sort | Yan Han |
| collection | DOAJ |
| description | ObjectivesPolycystic ovary syndrome (PCOS) is one of the most common endocrinopathy disorders in premenopausal women, which is characterized by hyperandrogenemia, anovulation, and polycystic ovarian morphology (PCOM). Time-restricted feeding (TRF) is a new intermittent restriction dietary pattern, which has been shown to have positive benefits on obesity and glycolipid metabolism disorders. We aimed to explore the effect of the feeding regimen (ad libitum vs. TRF) on the glycolipid metabolism and reproductive endocrine disorders in a PCOS mouse model.MethodsPCOS mouse model was induced by continuous subcutaneous administration of dihydrotestosterone for 21 days. Mice were fed a high-fat diet (HFD) for 8 weeks on an ad libitum or time- restricted diet (from 10:30 p.m. to 6:30 a.m.).ResultsCompared to control mice, PCOS mice that received TRF treatment had significantly lower body weight, reduced adiposity, lower area under the curve (AUC) of glucose response in the oral glucose tolerance test (OGTT), and lower AUC in the insulin tolerance test (ITT). TRF also ameliorated lipid metabolism, as shown by a reduction in plasma lipid profiles (triglycerides and cholesterol) and the triglyceride content in the liver of PCOS mice. In terms of reproduction, the plasma androgen level, plasma estrogen (E2) level, and luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio in PCOS mice were significantly reduced after 8 weeks of TRF treatment. In addition, ovarian histology showed that TRF inhibits cyst formation and promotes corpus luteum formation.ConclusionIn conclusion, TRF improved metabolic and endocrine profiles in mice with PCOS. |
| first_indexed | 2024-04-11T05:59:20Z |
| format | Article |
| id | doaj.art-1375e893dd7f4ce38d9f9a945728619e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T05:59:20Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1375e893dd7f4ce38d9f9a945728619e2022-12-22T04:41:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10573761057376Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndromeYan Han0Baiwei Lin1Wenjing Lu2Xu Wang3Xu Wang4Wenshuai Tang5Xinge Tao6Han Cai7Chunmei He8Changqin Liu9Changqin Liu10School of Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaSchool of Life Science, Anhui Medical University, Hefei, ChinaShanghai Key Laboratory of Metabolic Remodeling and Disease, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Metabolic Remodeling and Disease, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, Shanghai, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Endocrinology and Diabetes, the First Affiliated Hospital of Xiamen University, School of medicine, Xiamen University, Xiamen, ChinaDepartment of Endocrinology and Diabetes, the First Affiliated Hospital of Xiamen University, School of medicine, Xiamen University, Xiamen, ChinaFujian Province Key Laboratory of Diabetes Translational Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaObjectivesPolycystic ovary syndrome (PCOS) is one of the most common endocrinopathy disorders in premenopausal women, which is characterized by hyperandrogenemia, anovulation, and polycystic ovarian morphology (PCOM). Time-restricted feeding (TRF) is a new intermittent restriction dietary pattern, which has been shown to have positive benefits on obesity and glycolipid metabolism disorders. We aimed to explore the effect of the feeding regimen (ad libitum vs. TRF) on the glycolipid metabolism and reproductive endocrine disorders in a PCOS mouse model.MethodsPCOS mouse model was induced by continuous subcutaneous administration of dihydrotestosterone for 21 days. Mice were fed a high-fat diet (HFD) for 8 weeks on an ad libitum or time- restricted diet (from 10:30 p.m. to 6:30 a.m.).ResultsCompared to control mice, PCOS mice that received TRF treatment had significantly lower body weight, reduced adiposity, lower area under the curve (AUC) of glucose response in the oral glucose tolerance test (OGTT), and lower AUC in the insulin tolerance test (ITT). TRF also ameliorated lipid metabolism, as shown by a reduction in plasma lipid profiles (triglycerides and cholesterol) and the triglyceride content in the liver of PCOS mice. In terms of reproduction, the plasma androgen level, plasma estrogen (E2) level, and luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio in PCOS mice were significantly reduced after 8 weeks of TRF treatment. In addition, ovarian histology showed that TRF inhibits cyst formation and promotes corpus luteum formation.ConclusionIn conclusion, TRF improved metabolic and endocrine profiles in mice with PCOS.https://www.frontiersin.org/articles/10.3389/fendo.2022.1057376/fulltime-restricted feeding (TRF)glycolipid metabolismpolycystic ovary syndromedietary interventionendocrine profiles |
| spellingShingle | Yan Han Baiwei Lin Wenjing Lu Xu Wang Xu Wang Wenshuai Tang Xinge Tao Han Cai Chunmei He Changqin Liu Changqin Liu Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome Frontiers in Endocrinology time-restricted feeding (TRF) glycolipid metabolism polycystic ovary syndrome dietary intervention endocrine profiles |
| title | Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome |
| title_full | Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome |
| title_fullStr | Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome |
| title_full_unstemmed | Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome |
| title_short | Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome |
| title_sort | time restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome |
| topic | time-restricted feeding (TRF) glycolipid metabolism polycystic ovary syndrome dietary intervention endocrine profiles |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1057376/full |
| work_keys_str_mv | AT yanhan timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT baiweilin timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT wenjinglu timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT xuwang timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT xuwang timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT wenshuaitang timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT xingetao timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT hancai timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT chunmeihe timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT changqinliu timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome AT changqinliu timerestrictedfeedingimprovesmetabolicandendocrineprofilesinmicewithpolycysticovarysyndrome |