An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines. Here we report a novel interleukin (IL)-4 vs. IL-21 ICR...

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Bibliographic Details
Main Authors: Yi Wang, Hua Jiang, Hong Luo, Yansha Sun, Bizhi Shi, Ruixin Sun, Zonghai Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
CAR-T cells
inverted cytokine receptors
interleukin-4
interleukin-21
immunosuppressive tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01691/full

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