The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients
Sepsis represents a severe pathology that requires both rapid and precise positive and differential diagnosis to identify patients who need immediate antimicrobial therapy. Monitoring septic patients′ outcome leads to prolonged hospitalisation and antibacterial therapy, often accompanied by substant...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-07-01
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| Series: | The Journal of Critical Care Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/jccm-2017-0019 |
| _version_ | 1797421723937669120 |
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| author | Orfanu Alina Elena Popescu Cristina Leuștean Anca Negru Anca Ruxandra Tilişcan Cătălin Aramă Victoria Aramă Ștefan Sorin |
| author_facet | Orfanu Alina Elena Popescu Cristina Leuștean Anca Negru Anca Ruxandra Tilişcan Cătălin Aramă Victoria Aramă Ștefan Sorin |
| author_sort | Orfanu Alina Elena |
| collection | DOAJ |
| description | Sepsis represents a severe pathology that requires both rapid and precise positive and differential diagnosis to identify patients who need immediate antimicrobial therapy. Monitoring septic patients′ outcome leads to prolonged hospitalisation and antibacterial therapy, often accompanied by substantial side effects, complications and a high mortality risk. Septic patients present with complex pathophysiological and immunological disorders and with a predominance of pro-inflammatory or anti-inflammatory mediators which are heterogeneous with respect to the infectious focus, the aetiology of sepsis or patients′ immune status or comorbidities. Previous studies performed have analysed inflammatory biomarkers, but a test or combinations of tests that can quickly and precisely establish a diagnosis or prognosis of septic patients has yet to be discovered. Recent research has focused on re-analysing older accessible parameters found in the complete blood count to determine the sensitivity, specificity, positive and negative predictive values for the diagnosis and prognosis of sepsis. The neutrophil/lymphocyte count ratio (NLCR), mean platelet volume (MPV) and red blood cells distribution width (RDW) are haemogram indicators which have been evaluated and which are of proven use in septic patients′ management. |
| first_indexed | 2024-03-09T07:21:34Z |
| format | Article |
| id | doaj.art-137675cf9c034958b0292be018654ea7 |
| institution | Directory Open Access Journal |
| issn | 2393-1817 |
| language | English |
| last_indexed | 2024-03-09T07:21:34Z |
| publishDate | 2017-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | The Journal of Critical Care Medicine |
| spelling | doaj.art-137675cf9c034958b0292be018654ea72023-12-03T07:16:49ZengSciendoThe Journal of Critical Care Medicine2393-18172017-07-013310511010.1515/jccm-2017-0019jccm-2017-0019The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic PatientsOrfanu Alina Elena0Popescu Cristina1Leuștean Anca2Negru Anca Ruxandra3Tilişcan Cătălin4Aramă Victoria5Aramă Ștefan Sorin6National Institute for Infectious Diseases “Prof. Dr Matei Balș”, Dr Calistrat Grozovici Street, no 1, 021105, Bucharest, RomaniaNational Institute for Infectious Diseases “Prof. Dr Matei Balș”, Dr Calistrat Grozovici Street, no 1, 021105, Bucharest, RomaniaNational Institute for Infectious Diseases “Prof. Dr Matei Balș”, Dr Calistrat Grozovici Street, no 1, 021105, Bucharest, RomaniaNational Institute for Infectious Diseases “Prof. Dr Matei Balș”, Dr Calistrat Grozovici Street, no 1, 021105, Bucharest, RomaniaNational Institute for Infectious Diseases “Prof. Dr Matei Balș”, Dr Calistrat Grozovici Street, no 1, 021105, Bucharest, RomaniaNational Institute for Infectious Diseases “Prof. Dr Matei Balș”, Dr Calistrat Grozovici Street, no 1, 021105, Bucharest, RomaniaNational Institute for Infectious Diseases “Prof. Dr Matei Balș”, Dr Calistrat Grozovici Street, no 1, 021105, Bucharest, RomaniaSepsis represents a severe pathology that requires both rapid and precise positive and differential diagnosis to identify patients who need immediate antimicrobial therapy. Monitoring septic patients′ outcome leads to prolonged hospitalisation and antibacterial therapy, often accompanied by substantial side effects, complications and a high mortality risk. Septic patients present with complex pathophysiological and immunological disorders and with a predominance of pro-inflammatory or anti-inflammatory mediators which are heterogeneous with respect to the infectious focus, the aetiology of sepsis or patients′ immune status or comorbidities. Previous studies performed have analysed inflammatory biomarkers, but a test or combinations of tests that can quickly and precisely establish a diagnosis or prognosis of septic patients has yet to be discovered. Recent research has focused on re-analysing older accessible parameters found in the complete blood count to determine the sensitivity, specificity, positive and negative predictive values for the diagnosis and prognosis of sepsis. The neutrophil/lymphocyte count ratio (NLCR), mean platelet volume (MPV) and red blood cells distribution width (RDW) are haemogram indicators which have been evaluated and which are of proven use in septic patients′ management.https://doi.org/10.1515/jccm-2017-0019neutrophil/lymphocyte count ratiomean platelet volumered blood cells distribution widthsepsis |
| spellingShingle | Orfanu Alina Elena Popescu Cristina Leuștean Anca Negru Anca Ruxandra Tilişcan Cătălin Aramă Victoria Aramă Ștefan Sorin The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients The Journal of Critical Care Medicine neutrophil/lymphocyte count ratio mean platelet volume red blood cells distribution width sepsis |
| title | The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients |
| title_full | The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients |
| title_fullStr | The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients |
| title_full_unstemmed | The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients |
| title_short | The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients |
| title_sort | importance of haemogram parameters in the diagnosis and prognosis of septic patients |
| topic | neutrophil/lymphocyte count ratio mean platelet volume red blood cells distribution width sepsis |
| url | https://doi.org/10.1515/jccm-2017-0019 |
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