Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled Trial
Patients with Parkinson's disease (PD) have difficulties while performing dual-task activities, a condition present in everyday life. It is possible that strategies such as transcranial Direct Current Stimulation (tDCS) can be associated with motor training enriched with dual-task training to i...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-07-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.684689/full |
| _version_ | 1818624239050162176 |
|---|---|
| author | Adriana Costa-Ribeiro Suellen Mary Marinho dos Santos Andrade Mayane Laís Veloso Férrer Ozair Argentille Pereira Da Silva Maiara Llarena Silva Salvador Suhaila Smaili Ana Raquel Rodrigues Lindquist |
| author_facet | Adriana Costa-Ribeiro Suellen Mary Marinho dos Santos Andrade Mayane Laís Veloso Férrer Ozair Argentille Pereira Da Silva Maiara Llarena Silva Salvador Suhaila Smaili Ana Raquel Rodrigues Lindquist |
| author_sort | Adriana Costa-Ribeiro |
| collection | DOAJ |
| description | Patients with Parkinson's disease (PD) have difficulties while performing dual-task activities, a condition present in everyday life. It is possible that strategies such as transcranial Direct Current Stimulation (tDCS) can be associated with motor training enriched with dual-task training to improve the performance of two concurrent tasks. Currently, it is unclear whether specific tasks and clinical conditions of PD patients have different results after the intervention. Therefore, the proposed randomized controlled trial will examine task-dependency in enhancing the effects of tDCS-linked rehabilitation training on PD and the relationships between baseline outcomes in responders and non-responders to therapy. Fifty-six patients with Parkinson's disease will be recruited to participate in this controlled, double-blind randomized multicentric clinical trial. Patients in modified Hoehn & Yahr stage 1.5–3, age between 40 and 70 years will be included. Subjects will be randomly assigned to an experimental group (EG) and a control group (CG). The EG will perform treadmill gait training associated with dual task exercises+tDCS, while the CG will only engage in treadmill gait training+tDCS. Blinded testers will assess patients before and after 12 intervention sessions and after a 4-week follow-up period. All patients will undergo a screening and an initial visit before being assessed for primary and secondary outcomes. The primary outcome measure is functional mobility measured by Timed Up and Go Test. Secondary outcomes include cognitive function, participation, motor function and body function and structure. This study will evaluate the effectiveness of an intervention protocol with tDCS, dual-task training and gait training in patients with PD. The study will also highlight the clinical factors and variability between individuals that could interfere in the training of a specific task and influence the therapeutic effect.Clinical Trial registration: www.ClinicalTrials.gov, identifier NCT04581590. |
| first_indexed | 2024-12-16T18:53:47Z |
| format | Article |
| id | doaj.art-13773e0f2de249b5b1f56da55a62e081 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-16T18:53:47Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-13773e0f2de249b5b1f56da55a62e0812022-12-21T22:20:36ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-07-011310.3389/fnagi.2021.684689684689Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled TrialAdriana Costa-Ribeiro0Suellen Mary Marinho dos Santos Andrade1Mayane Laís Veloso Férrer2Ozair Argentille Pereira Da Silva3Maiara Llarena Silva Salvador4Suhaila Smaili5Ana Raquel Rodrigues Lindquist6NeuroMove Laboratory, Department of Physiotherapy, Federal University of Paraíba, Campus I Cidade Universitária, Joao Pessoa, BrazilNeuroscience and Aging Laboratory, Federal University of Paraíba, Campus I Cidade Universitária, Joao Pessoa, BrazilNeuroMove Laboratory, Department of Physiotherapy, Federal University of Paraíba, Campus I Cidade Universitária, Joao Pessoa, BrazilLaboratory of Intervention and Analysis of Movement, Department of Physiotherapy, Federal University of Rio Grande do Norte, Campus Universitário, Natal, BrazilNeuroscience and Aging Laboratory, Federal University of Paraíba, Campus I Cidade Universitária, Joao Pessoa, BrazilDepartment of Physiotherapy, State University of Londrina, Londrina, BrazilLaboratory of Intervention and Analysis of Movement, Department of Physiotherapy, Federal University of Rio Grande do Norte, Campus Universitário, Natal, BrazilPatients with Parkinson's disease (PD) have difficulties while performing dual-task activities, a condition present in everyday life. It is possible that strategies such as transcranial Direct Current Stimulation (tDCS) can be associated with motor training enriched with dual-task training to improve the performance of two concurrent tasks. Currently, it is unclear whether specific tasks and clinical conditions of PD patients have different results after the intervention. Therefore, the proposed randomized controlled trial will examine task-dependency in enhancing the effects of tDCS-linked rehabilitation training on PD and the relationships between baseline outcomes in responders and non-responders to therapy. Fifty-six patients with Parkinson's disease will be recruited to participate in this controlled, double-blind randomized multicentric clinical trial. Patients in modified Hoehn & Yahr stage 1.5–3, age between 40 and 70 years will be included. Subjects will be randomly assigned to an experimental group (EG) and a control group (CG). The EG will perform treadmill gait training associated with dual task exercises+tDCS, while the CG will only engage in treadmill gait training+tDCS. Blinded testers will assess patients before and after 12 intervention sessions and after a 4-week follow-up period. All patients will undergo a screening and an initial visit before being assessed for primary and secondary outcomes. The primary outcome measure is functional mobility measured by Timed Up and Go Test. Secondary outcomes include cognitive function, participation, motor function and body function and structure. This study will evaluate the effectiveness of an intervention protocol with tDCS, dual-task training and gait training in patients with PD. The study will also highlight the clinical factors and variability between individuals that could interfere in the training of a specific task and influence the therapeutic effect.Clinical Trial registration: www.ClinicalTrials.gov, identifier NCT04581590.https://www.frontiersin.org/articles/10.3389/fnagi.2021.684689/fullParkinson's diseasetranscranial direct current stimulationphysical therapydual-taskcognitionstudy protocol |
| spellingShingle | Adriana Costa-Ribeiro Suellen Mary Marinho dos Santos Andrade Mayane Laís Veloso Férrer Ozair Argentille Pereira Da Silva Maiara Llarena Silva Salvador Suhaila Smaili Ana Raquel Rodrigues Lindquist Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled Trial Frontiers in Aging Neuroscience Parkinson's disease transcranial direct current stimulation physical therapy dual-task cognition study protocol |
| title | Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled Trial |
| title_full | Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled Trial |
| title_fullStr | Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled Trial |
| title_full_unstemmed | Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled Trial |
| title_short | Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled Trial |
| title_sort | can task specificity impact tdcs linked to dual task training gains in parkinson s disease a protocol for a randomized controlled trial |
| topic | Parkinson's disease transcranial direct current stimulation physical therapy dual-task cognition study protocol |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.684689/full |
| work_keys_str_mv | AT adrianacostaribeiro cantaskspecificityimpacttdcslinkedtodualtasktraininggainsinparkinsonsdiseaseaprotocolforarandomizedcontrolledtrial AT suellenmarymarinhodossantosandrade cantaskspecificityimpacttdcslinkedtodualtasktraininggainsinparkinsonsdiseaseaprotocolforarandomizedcontrolledtrial AT mayanelaisvelosoferrer cantaskspecificityimpacttdcslinkedtodualtasktraininggainsinparkinsonsdiseaseaprotocolforarandomizedcontrolledtrial AT ozairargentillepereiradasilva cantaskspecificityimpacttdcslinkedtodualtasktraininggainsinparkinsonsdiseaseaprotocolforarandomizedcontrolledtrial AT maiarallarenasilvasalvador cantaskspecificityimpacttdcslinkedtodualtasktraininggainsinparkinsonsdiseaseaprotocolforarandomizedcontrolledtrial AT suhailasmaili cantaskspecificityimpacttdcslinkedtodualtasktraininggainsinparkinsonsdiseaseaprotocolforarandomizedcontrolledtrial AT anaraquelrodrigueslindquist cantaskspecificityimpacttdcslinkedtodualtasktraininggainsinparkinsonsdiseaseaprotocolforarandomizedcontrolledtrial |