Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats
Objectives: Obesity as a consequence of high fat diet (HFD) has become an uprising major global health problem with multiorgan affection. Quercetin proved a unique ameliorative potential against hazards of HFD. Methods: Forty rats were divided into four groups. Group I: Control group (10% of energy...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of King Saud University: Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364722001276 |
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| author | Rabab Ahmed Rasheed Mohamed S. Elshikh Mohamed Othman Mohamed Mohamed Faisal Darweesh Dina S. Hussein Saeedah Musaed Almutairi Azza Saleh Embaby |
| author_facet | Rabab Ahmed Rasheed Mohamed S. Elshikh Mohamed Othman Mohamed Mohamed Faisal Darweesh Dina S. Hussein Saeedah Musaed Almutairi Azza Saleh Embaby |
| author_sort | Rabab Ahmed Rasheed |
| collection | DOAJ |
| description | Objectives: Obesity as a consequence of high fat diet (HFD) has become an uprising major global health problem with multiorgan affection. Quercetin proved a unique ameliorative potential against hazards of HFD. Methods: Forty rats were divided into four groups. Group I: Control group (10% of energy from fat). Group II: (10% of energy from fat +50 mg/kg quercetin). Group III: (60% of energy from fat). Group IV: (60% of energy from fat +50 mg/kg quercetin). After12 weeks, all rats were sacrificed, kidney and pancreas were taken and processed for H&E, Mallory’s trichrome stains and immunohistochemical examination. Results: Both pancreatic and renal tissues showed histopathological degenerative and inflammatory changes in group III that was markedly improved in group IV treated with quercetin. Concerning the mean area percent of collagen fibers and Bcl-2 expression in both renal and pancreatic tissues that showed a highly significant difference in group III (p < 0.001) as compared to all other groups and a highly significant difference (p < 0.001) in group IV compared to group III. Conclusion: These results confirmed the negative influence of HFD intake on both renal and pancreatic tissues and the protective effect of concomitant use of quercetin. Quercetin's therapeutic potential for metabolic disorders may become more evident and widely accepted. |
| first_indexed | 2024-12-12T09:06:11Z |
| format | Article |
| id | doaj.art-137740273a624d68a043bba039638747 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-12-12T09:06:11Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-137740273a624d68a043bba0396387472022-12-22T00:29:40ZengElsevierJournal of King Saud University: Science1018-36472022-06-01344101946Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino ratsRabab Ahmed Rasheed0Mohamed S. Elshikh1Mohamed Othman Mohamed2Mohamed Faisal Darweesh3Dina S. Hussein4Saeedah Musaed Almutairi5Azza Saleh Embaby6Histology & Cell Biology Department, Faculty of Medicine, King Salman International University, South Sinai, Egypt; Corresponding authors.Department of Botany and Microbiology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi ArabiaAnatomy Department, Faculty of Medicine, King Salman International University, South Sinai, EgyptPathology Department, Faculty of Medicine, King Salman International University, South Sinai, EgyptDepartment of Chemistry, College of Sciences and Health, Cleveland State University, Cleveland 44115, United StatesDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi ArabiaMedical Histology & Cell Biology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, EgyptObjectives: Obesity as a consequence of high fat diet (HFD) has become an uprising major global health problem with multiorgan affection. Quercetin proved a unique ameliorative potential against hazards of HFD. Methods: Forty rats were divided into four groups. Group I: Control group (10% of energy from fat). Group II: (10% of energy from fat +50 mg/kg quercetin). Group III: (60% of energy from fat). Group IV: (60% of energy from fat +50 mg/kg quercetin). After12 weeks, all rats were sacrificed, kidney and pancreas were taken and processed for H&E, Mallory’s trichrome stains and immunohistochemical examination. Results: Both pancreatic and renal tissues showed histopathological degenerative and inflammatory changes in group III that was markedly improved in group IV treated with quercetin. Concerning the mean area percent of collagen fibers and Bcl-2 expression in both renal and pancreatic tissues that showed a highly significant difference in group III (p < 0.001) as compared to all other groups and a highly significant difference (p < 0.001) in group IV compared to group III. Conclusion: These results confirmed the negative influence of HFD intake on both renal and pancreatic tissues and the protective effect of concomitant use of quercetin. Quercetin's therapeutic potential for metabolic disorders may become more evident and widely accepted.http://www.sciencedirect.com/science/article/pii/S1018364722001276HFDQuercetinPancreasKidneyMetabolic disorders |
| spellingShingle | Rabab Ahmed Rasheed Mohamed S. Elshikh Mohamed Othman Mohamed Mohamed Faisal Darweesh Dina S. Hussein Saeedah Musaed Almutairi Azza Saleh Embaby Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats Journal of King Saud University: Science HFD Quercetin Pancreas Kidney Metabolic disorders |
| title | Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats |
| title_full | Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats |
| title_fullStr | Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats |
| title_full_unstemmed | Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats |
| title_short | Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats |
| title_sort | quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats |
| topic | HFD Quercetin Pancreas Kidney Metabolic disorders |
| url | http://www.sciencedirect.com/science/article/pii/S1018364722001276 |
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