Relevance of Plasma Homocysteine and Methylenetetrahydrofolate Reductase 677TT Genotype in Sickle Cell Disease: A Systematic Review and Meta-Analysis

Relevance of Plasma Homocysteine and Methylenetetrahydrofolate Reductase 677TT Genotype in Sickle Cell Disease: A Systematic Review and Meta-Analysis

We evaluated the relevance of plasma homocysteine (HC) and the TT genotype of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in sickle cell disease (SCD) and associated vaso-occlusive crisis (VOC) and ischemic stroke (IS). We identified in Embase and Medline 22 studie...

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Bibliographic Details
Main Authors: Paul R. J. Ames, Alessia Arcaro, Matilde Caruso, Maria Graf, Vincenzo Marottoli, Fabrizio Gentile
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
homocysteine
methylenetetrahydrofolate reductase
MTHFR TT genotype
sickle cell disease
vaso-occlusive crisis
ischemic stroke
Online Access:https://www.mdpi.com/1422-0067/23/23/14641

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