Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity
Even though radiation therapy has achieved great success, there is still an unsolved task of increasing radiation damage to tumor tissue and reducing side effects on healthy tissues. There is a wide variety of obstacles that reduce the efficiency of radiotherapy. Mechanisms of radioresistance involv...
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2023-09-01
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| Series: | International Journal of Biomedicine |
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| Online Access: | http://www.ijbm.org/articles/i51/ijbm_13(3)_ra2.pdf |
| _version_ | 1797690904381751296 |
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| author | Juan C. Alamilla-Presuel |
| author_facet | Juan C. Alamilla-Presuel |
| author_sort | Juan C. Alamilla-Presuel |
| collection | DOAJ |
| description | Even though radiation therapy has achieved great success, there is still an unsolved task of increasing radiation damage to tumor tissue and reducing side effects on healthy tissues. There is a wide variety of obstacles that reduce the efficiency of radiotherapy. Mechanisms of radioresistance involve tumor-specific oncogenic signalling pathways, tumor metabolism and proliferation, tumor microenvironment/hypoxia, and genomics. Radiosensitizers are promising agents that enhance injury to tumor tissue by accelerating DNA damage. Several strategies have been used recently to develop highly effective radiosensitizers with low toxicity. In this review, we considered the use of radiosensitizers, including small molecules and nanomaterials, in various malignant tumors and the problems and prospects for their clinical use in cancer therapy. |
| first_indexed | 2024-03-12T02:06:47Z |
| format | Article |
| id | doaj.art-137b62c1e93f400eae44c0ed418c112e |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-03-12T02:06:47Z |
| publishDate | 2023-09-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-137b62c1e93f400eae44c0ed418c112e2023-09-07T04:41:19ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292023-09-01133173010.21103/Article13(3)_RA2Radiosensitization: Studies and Modern Approaches to Cellular RadiosensitivityJuan C. Alamilla-Presuel0The University of Málaga, Málaga, SpainEven though radiation therapy has achieved great success, there is still an unsolved task of increasing radiation damage to tumor tissue and reducing side effects on healthy tissues. There is a wide variety of obstacles that reduce the efficiency of radiotherapy. Mechanisms of radioresistance involve tumor-specific oncogenic signalling pathways, tumor metabolism and proliferation, tumor microenvironment/hypoxia, and genomics. Radiosensitizers are promising agents that enhance injury to tumor tissue by accelerating DNA damage. Several strategies have been used recently to develop highly effective radiosensitizers with low toxicity. In this review, we considered the use of radiosensitizers, including small molecules and nanomaterials, in various malignant tumors and the problems and prospects for their clinical use in cancer therapy.http://www.ijbm.org/articles/i51/ijbm_13(3)_ra2.pdfionizing radiationradiosensitizercellular radiosensitivitytumor tissuedna damage |
| spellingShingle | Juan C. Alamilla-Presuel Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity International Journal of Biomedicine ionizing radiation radiosensitizer cellular radiosensitivity tumor tissue dna damage |
| title | Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity |
| title_full | Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity |
| title_fullStr | Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity |
| title_full_unstemmed | Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity |
| title_short | Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity |
| title_sort | radiosensitization studies and modern approaches to cellular radiosensitivity |
| topic | ionizing radiation radiosensitizer cellular radiosensitivity tumor tissue dna damage |
| url | http://www.ijbm.org/articles/i51/ijbm_13(3)_ra2.pdf |
| work_keys_str_mv | AT juancalamillapresuel radiosensitizationstudiesandmodernapproachestocellularradiosensitivity |