Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement

Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement

Abstract Background Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the component of gastric duodenal contents, has been recognised as a carcinogen. B...

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Bibliographic Details
Main Authors: Sang-Nee Tan, Sai-Peng Sim
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
CRS
NPC
Nasopharyngeal reflux
BA
Apoptosis
AF9
Online Access:http://link.springer.com/article/10.1186/s12885-018-4327-4

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