Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials.
<h4>Objectives</h4>We aimed to conduct a systematic review on published data in order to investigate the efficacy of mouthwash products containing chlorine dioxide in halitosis.<h4>Study design</h4>Systematic review and meta-analysis.<h4>Methods</h4>Our search was...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0280377 |
| _version_ | 1797943972203593728 |
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| author | Eszter Szalai Péter Tajti Bence Szabó Péter Hegyi László Márk Czumbel Saghar Shojazadeh Gábor Varga Orsolya Németh Beata Keremi |
| author_facet | Eszter Szalai Péter Tajti Bence Szabó Péter Hegyi László Márk Czumbel Saghar Shojazadeh Gábor Varga Orsolya Németh Beata Keremi |
| author_sort | Eszter Szalai |
| collection | DOAJ |
| description | <h4>Objectives</h4>We aimed to conduct a systematic review on published data in order to investigate the efficacy of mouthwash products containing chlorine dioxide in halitosis.<h4>Study design</h4>Systematic review and meta-analysis.<h4>Methods</h4>Our search was conducted on 14th October 2021. We searched the following electronic databases: MEDLINE, Embase, Scopus, Web of Science, and CENTRAL. We analysed data on adults with halitosis, included only randomised controlled trials and excluded in vitro and animal studies. The interventional groups used chlorine dioxide, and the comparator groups used a placebo or other mouthwash. Our primary outcomes were changes in organoleptic test scores (OLS) and Volatile Sulfur Compound (VSC) levels from baseline to the last available follow-up.<h4>Results</h4>We found 325 articles in databases. After the selection process, ten articles were eligible for qualitative synthesis, and 7 RCTs with 234 patients were involved in the meta-analysis. Our findings showed a significant improvement in the parameters of the chlorine dioxide group compared to the placebo group in OLS one-day data (mean difference (MD): -0.82; 95% confidence intervals (95% CIs): [-1.04 --0.6]; heterogeneity: I2 = 0%, p = 0.67); and one-week OLS data (MD: -0.24; 95% CIs: [-0.41 --0.07]; I2 = 0%, p = 0.52); and also changes in H2S one-day data (standardised mean difference (SMD): -1.81; 95% CIs: [-2.52 --1.10]); I2 = 73.4%, p = 0.02).<h4>Conclusion</h4>Our data indicate that chlorine dioxide mouthwash may be a good supportive therapy in oral halitosis without known side effects. |
| first_indexed | 2024-04-10T20:32:30Z |
| format | Article |
| id | doaj.art-137be55b881a490c85555c18265d6fe2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T20:32:30Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-137be55b881a490c85555c18265d6fe22023-01-25T05:32:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181e028037710.1371/journal.pone.0280377Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials.Eszter SzalaiPéter TajtiBence SzabóPéter HegyiLászló Márk CzumbelSaghar ShojazadehGábor VargaOrsolya NémethBeata Keremi<h4>Objectives</h4>We aimed to conduct a systematic review on published data in order to investigate the efficacy of mouthwash products containing chlorine dioxide in halitosis.<h4>Study design</h4>Systematic review and meta-analysis.<h4>Methods</h4>Our search was conducted on 14th October 2021. We searched the following electronic databases: MEDLINE, Embase, Scopus, Web of Science, and CENTRAL. We analysed data on adults with halitosis, included only randomised controlled trials and excluded in vitro and animal studies. The interventional groups used chlorine dioxide, and the comparator groups used a placebo or other mouthwash. Our primary outcomes were changes in organoleptic test scores (OLS) and Volatile Sulfur Compound (VSC) levels from baseline to the last available follow-up.<h4>Results</h4>We found 325 articles in databases. After the selection process, ten articles were eligible for qualitative synthesis, and 7 RCTs with 234 patients were involved in the meta-analysis. Our findings showed a significant improvement in the parameters of the chlorine dioxide group compared to the placebo group in OLS one-day data (mean difference (MD): -0.82; 95% confidence intervals (95% CIs): [-1.04 --0.6]; heterogeneity: I2 = 0%, p = 0.67); and one-week OLS data (MD: -0.24; 95% CIs: [-0.41 --0.07]; I2 = 0%, p = 0.52); and also changes in H2S one-day data (standardised mean difference (SMD): -1.81; 95% CIs: [-2.52 --1.10]); I2 = 73.4%, p = 0.02).<h4>Conclusion</h4>Our data indicate that chlorine dioxide mouthwash may be a good supportive therapy in oral halitosis without known side effects.https://doi.org/10.1371/journal.pone.0280377 |
| spellingShingle | Eszter Szalai Péter Tajti Bence Szabó Péter Hegyi László Márk Czumbel Saghar Shojazadeh Gábor Varga Orsolya Németh Beata Keremi Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials. PLoS ONE |
| title | Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials. |
| title_full | Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials. |
| title_fullStr | Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials. |
| title_full_unstemmed | Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials. |
| title_short | Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials. |
| title_sort | daily use of chlorine dioxide effectively treats halitosis a meta analysis of randomised controlled trials |
| url | https://doi.org/10.1371/journal.pone.0280377 |
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