Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation
Flavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called rep...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/1060 |
| _version_ | 1797531492457381888 |
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| author | Eiji Morita Youichi Suzuki |
| author_facet | Eiji Morita Youichi Suzuki |
| author_sort | Eiji Morita |
| collection | DOAJ |
| description | Flavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called replication organelle is considered as a microenvironment that provides factors required for the activity of the flaviviral replication complex. The replication organelle serves as a place to coordinate viral RNA amplification, protein translation, and virion assembly and also to protect the viral replication complex from the cellular immune defense system. In this review, we summarize the current understanding of how the formation and function of membrane-associated flaviviral replication organelle are regulated by cellular factors. |
| first_indexed | 2024-03-10T10:44:34Z |
| format | Article |
| id | doaj.art-137c22d276f545669f20ec710fba4482 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:44:34Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-137c22d276f545669f20ec710fba44822023-11-21T22:40:48ZengMDPI AGViruses1999-49152021-06-01136106010.3390/v13061060Membrane-Associated Flavivirus Replication Complex—Its Organization and RegulationEiji Morita0Youichi Suzuki1Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki-shi 036-8561, JapanDepartment of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki 569-8686, JapanFlavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called replication organelle is considered as a microenvironment that provides factors required for the activity of the flaviviral replication complex. The replication organelle serves as a place to coordinate viral RNA amplification, protein translation, and virion assembly and also to protect the viral replication complex from the cellular immune defense system. In this review, we summarize the current understanding of how the formation and function of membrane-associated flaviviral replication organelle are regulated by cellular factors.https://www.mdpi.com/1999-4915/13/6/1060flavivirusreplication complexreplication organelleendoplasmic reticulummembranous microenvironmentcellular factors |
| spellingShingle | Eiji Morita Youichi Suzuki Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation Viruses flavivirus replication complex replication organelle endoplasmic reticulum membranous microenvironment cellular factors |
| title | Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation |
| title_full | Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation |
| title_fullStr | Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation |
| title_full_unstemmed | Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation |
| title_short | Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation |
| title_sort | membrane associated flavivirus replication complex its organization and regulation |
| topic | flavivirus replication complex replication organelle endoplasmic reticulum membranous microenvironment cellular factors |
| url | https://www.mdpi.com/1999-4915/13/6/1060 |
| work_keys_str_mv | AT eijimorita membraneassociatedflavivirusreplicationcomplexitsorganizationandregulation AT youichisuzuki membraneassociatedflavivirusreplicationcomplexitsorganizationandregulation |