RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients
Abstract Introduction: Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries. Our objective in this study is to investi...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
2021-12-01
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382021005008215&tlng=en |
| _version_ | 1811246476903317504 |
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| author | Eda Dokumacioglu Ibrahim Duzcan Hatice Iskender Arzu Sahin |
| author_facet | Eda Dokumacioglu Ibrahim Duzcan Hatice Iskender Arzu Sahin |
| author_sort | Eda Dokumacioglu |
| collection | DOAJ |
| description | Abstract Introduction: Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries. Our objective in this study is to investigate the RhoA/Rho-associated kinase (ROCK)-1 signaling pathway and oxidative stress in CAD patients. Methods: A total of 81 individuals aged between 40-70 years - including 45 patients (15 females and 30 males) who were admitted to the Artvin State Hospital Cardiovascular Surgery Clinic and were diagnosed with CAD and 36 healthy volunteers (15 females and 21 males) - participated in this study. Serum samples were tested for total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, malondialdehyde (MDA), superoxide dismutase (SOD), RhoA, and ROCK-1 values. Results: Serum RhoA, MDA levels, and ROCK-1 activity in the CAD group were found to be statistically significantly higher than in the control group (P<0.001). Concordantly, serum SOD activity was found to be statistically significantly lower in the CAD group than in the control group (P<0.001). Conclusion: Inhibition of the activity of RhoA/ROCK-1 pathway would be beneficial in treating cardiovascular diseases since this pathway plays an important role in the development of these diseases. |
| first_indexed | 2024-04-12T14:54:01Z |
| format | Article |
| id | doaj.art-137e6955e7cd4da2a1a50076b56f1f42 |
| institution | Directory Open Access Journal |
| issn | 1678-9741 |
| language | English |
| last_indexed | 2024-04-12T14:54:01Z |
| publishDate | 2021-12-01 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-137e6955e7cd4da2a1a50076b56f1f422022-12-22T03:28:19ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-97412021-12-0110.21470/1678-9741-2020-0525RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease PatientsEda Dokumaciogluhttps://orcid.org/0000-0002-2223-1331Ibrahim DuzcanHatice IskenderArzu SahinAbstract Introduction: Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries. Our objective in this study is to investigate the RhoA/Rho-associated kinase (ROCK)-1 signaling pathway and oxidative stress in CAD patients. Methods: A total of 81 individuals aged between 40-70 years - including 45 patients (15 females and 30 males) who were admitted to the Artvin State Hospital Cardiovascular Surgery Clinic and were diagnosed with CAD and 36 healthy volunteers (15 females and 21 males) - participated in this study. Serum samples were tested for total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, malondialdehyde (MDA), superoxide dismutase (SOD), RhoA, and ROCK-1 values. Results: Serum RhoA, MDA levels, and ROCK-1 activity in the CAD group were found to be statistically significantly higher than in the control group (P<0.001). Concordantly, serum SOD activity was found to be statistically significantly lower in the CAD group than in the control group (P<0.001). Conclusion: Inhibition of the activity of RhoA/ROCK-1 pathway would be beneficial in treating cardiovascular diseases since this pathway plays an important role in the development of these diseases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382021005008215&tlng=enCoronary Artery DiseaseMalondialdehydeRHOA protein, humanRho-Associated KinasesOxidative StressSuperoxide DismutaseSignal Transduction |
| spellingShingle | Eda Dokumacioglu Ibrahim Duzcan Hatice Iskender Arzu Sahin RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients Brazilian Journal of Cardiovascular Surgery Coronary Artery Disease Malondialdehyde RHOA protein, human Rho-Associated Kinases Oxidative Stress Superoxide Dismutase Signal Transduction |
| title | RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients |
| title_full | RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients |
| title_fullStr | RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients |
| title_full_unstemmed | RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients |
| title_short | RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients |
| title_sort | rhoa rock 1 signaling pathway and oxidative stress in coronary artery disease patients |
| topic | Coronary Artery Disease Malondialdehyde RHOA protein, human Rho-Associated Kinases Oxidative Stress Superoxide Dismutase Signal Transduction |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382021005008215&tlng=en |
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