High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis
<p>Abstract</p> <p>To test the carcinostatic effects of ascorbic acid, we challenged the mice of seven experimental groups with 1.7 × 10<sup>-4 </sup>mol high dose concentration ascorbic acid after intraperitoneal administrating them with sarcoma S-180 cells. The surviv...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-08-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/7/1/70 |
| _version_ | 1811285656055316480 |
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| author | Lee Hye Yi Sang-Yeop Park Seyeon Yu Jaelim Park Jin-Hee Lee Gunsup Yeom Chang-Hwan Hong Young Yang Joosung Lee Sukchan |
| author_facet | Lee Hye Yi Sang-Yeop Park Seyeon Yu Jaelim Park Jin-Hee Lee Gunsup Yeom Chang-Hwan Hong Young Yang Joosung Lee Sukchan |
| author_sort | Lee Hye |
| collection | DOAJ |
| description | <p>Abstract</p> <p>To test the carcinostatic effects of ascorbic acid, we challenged the mice of seven experimental groups with 1.7 × 10<sup>-4 </sup>mol high dose concentration ascorbic acid after intraperitoneal administrating them with sarcoma S-180 cells. The survival rate was increased by 20% in the group that received high dose concentration ascorbic acid, compared to the control. The highest survival rate was observed in the group in which 1.7 × 10<sup>-4 </sup>mol ascorbic acid had been continuously injected before and after the induction of cancer cells, rather than just after the induction of cancer cells. The expression of three angiogenesis-related genes was inhibited by 0.3 times in bFGF, 7 times in VEGF and 4 times in MMP2 of the groups with higher survival rates. Biopsy Results, gene expression studies, and wound healing analysis <it>in vivo </it>and <it>in vitro </it>suggested that the carcinostatic effect induced by high dose concentration ascorbic acid occurred through inhibition of angiogenesis.</p> |
| first_indexed | 2024-04-13T02:47:23Z |
| format | Article |
| id | doaj.art-137ed6e68ce242cb96af5c20cde060c0 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-13T02:47:23Z |
| publishDate | 2009-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-137ed6e68ce242cb96af5c20cde060c02022-12-22T03:05:57ZengBMCJournal of Translational Medicine1479-58762009-08-01717010.1186/1479-5876-7-70High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesisLee HyeYi Sang-YeopPark SeyeonYu JaelimPark Jin-HeeLee GunsupYeom Chang-HwanHong YoungYang JoosungLee Sukchan<p>Abstract</p> <p>To test the carcinostatic effects of ascorbic acid, we challenged the mice of seven experimental groups with 1.7 × 10<sup>-4 </sup>mol high dose concentration ascorbic acid after intraperitoneal administrating them with sarcoma S-180 cells. The survival rate was increased by 20% in the group that received high dose concentration ascorbic acid, compared to the control. The highest survival rate was observed in the group in which 1.7 × 10<sup>-4 </sup>mol ascorbic acid had been continuously injected before and after the induction of cancer cells, rather than just after the induction of cancer cells. The expression of three angiogenesis-related genes was inhibited by 0.3 times in bFGF, 7 times in VEGF and 4 times in MMP2 of the groups with higher survival rates. Biopsy Results, gene expression studies, and wound healing analysis <it>in vivo </it>and <it>in vitro </it>suggested that the carcinostatic effect induced by high dose concentration ascorbic acid occurred through inhibition of angiogenesis.</p>http://www.translational-medicine.com/content/7/1/70 |
| spellingShingle | Lee Hye Yi Sang-Yeop Park Seyeon Yu Jaelim Park Jin-Hee Lee Gunsup Yeom Chang-Hwan Hong Young Yang Joosung Lee Sukchan High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis Journal of Translational Medicine |
| title | High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis |
| title_full | High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis |
| title_fullStr | High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis |
| title_full_unstemmed | High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis |
| title_short | High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis |
| title_sort | high dose concentration administration of ascorbic acid inhibits tumor growth in balb c mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis |
| url | http://www.translational-medicine.com/content/7/1/70 |
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