Temporary HMCES-DNA cross-link prevents permanent DNA damage
HMCES, a recently discovered but ancient protein, covalently attaches to damaged single-stranded DNA and shields it from nucleases. Rua-Fernandez and colleagues now show that HMCES catalyzes its own recycling, permitting normal growth and non-mutagenic DNA repair.1
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723016066 |
| _version_ | 1797377810894946304 |
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| author | Penelope D. Ruiz Agata Smogorzewska |
| author_facet | Penelope D. Ruiz Agata Smogorzewska |
| author_sort | Penelope D. Ruiz |
| collection | DOAJ |
| description | HMCES, a recently discovered but ancient protein, covalently attaches to damaged single-stranded DNA and shields it from nucleases. Rua-Fernandez and colleagues now show that HMCES catalyzes its own recycling, permitting normal growth and non-mutagenic DNA repair.1 |
| first_indexed | 2024-03-08T19:58:48Z |
| format | Article |
| id | doaj.art-1382a39ec82341e488ae05ef8dcf22ab |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T19:58:48Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-1382a39ec82341e488ae05ef8dcf22ab2023-12-24T04:45:25ZengElsevierCell Reports2211-12472024-01-01431113594Temporary HMCES-DNA cross-link prevents permanent DNA damagePenelope D. Ruiz0Agata Smogorzewska1Laboratory of Genome Maintenance, The Rockefeller University, New York, NY, USALaboratory of Genome Maintenance, The Rockefeller University, New York, NY, USA; Corresponding authorHMCES, a recently discovered but ancient protein, covalently attaches to damaged single-stranded DNA and shields it from nucleases. Rua-Fernandez and colleagues now show that HMCES catalyzes its own recycling, permitting normal growth and non-mutagenic DNA repair.1http://www.sciencedirect.com/science/article/pii/S2211124723016066 |
| spellingShingle | Penelope D. Ruiz Agata Smogorzewska Temporary HMCES-DNA cross-link prevents permanent DNA damage Cell Reports |
| title | Temporary HMCES-DNA cross-link prevents permanent DNA damage |
| title_full | Temporary HMCES-DNA cross-link prevents permanent DNA damage |
| title_fullStr | Temporary HMCES-DNA cross-link prevents permanent DNA damage |
| title_full_unstemmed | Temporary HMCES-DNA cross-link prevents permanent DNA damage |
| title_short | Temporary HMCES-DNA cross-link prevents permanent DNA damage |
| title_sort | temporary hmces dna cross link prevents permanent dna damage |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723016066 |
| work_keys_str_mv | AT penelopedruiz temporaryhmcesdnacrosslinkpreventspermanentdnadamage AT agatasmogorzewska temporaryhmcesdnacrosslinkpreventspermanentdnadamage |