Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non-haematological patients: protocol for a systematic review and meta-analysis
Introduction Increasing numbers of patients with non-haematological diseases are infected with invasive pulmonary aspergillosis (IPA), with a high mortality reported which is mainly due to delayed diagnosis. The diagnostic capability of mycological tests for IPA including galactomannan test, (1,3)-β...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/8/e057746.full |
| _version_ | 1797999723218468864 |
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| author | Wei Xiao Long-yi Du Bing Mao Ti-wei Miao Juan-juan Fu Yu Li Meilu Liu Guilan Cheng Chan Xiong |
| author_facet | Wei Xiao Long-yi Du Bing Mao Ti-wei Miao Juan-juan Fu Yu Li Meilu Liu Guilan Cheng Chan Xiong |
| author_sort | Wei Xiao |
| collection | DOAJ |
| description | Introduction Increasing numbers of patients with non-haematological diseases are infected with invasive pulmonary aspergillosis (IPA), with a high mortality reported which is mainly due to delayed diagnosis. The diagnostic capability of mycological tests for IPA including galactomannan test, (1,3)-β-D-glucan test, lateral flow assay, lateral flow device and PCR for the non-haematological patients remains unknown. This protocol aims to conduct a systematic review and meta-analysis of the diagnostic performance of mycological tests to facilitate the early diagnosis and treatments of IPA in non-haematological diseases.Methods and analysis Database including PubMed, CENTRAL and EMBASE will be searched from 2002 until the publication of results. Cohort or cross-sectional studies that assessing the diagnostic capability of mycological tests for IPA in patients with non-haematological diseases will be included. The true-positive, false-positive, true-negative and false-negative of each test will be extracted and pooled in bivariate random-effects model, by which the sensitivity and specificity will be calculated with 95% CI. The second outcomes will include positive (negative) likelihood ratio, area under the receiver operating characteristic curve and diagnostic OR will also be computed in the bivariate model. When applicable, subgroup analysis will be performed with several prespecified covariates to explore potential sources of heterogeneity. Factors that may impact the diagnostic effects of mycological tests will be examined by sensitivity analysis. The risk of bias will be appraised by the Quality Assessment tool for Diagnostic Accuracy Studies (QUADAS-2).Ethics and dissemination This protocol is not involved with ethics approval, and the results will be peer-reviewed and disseminated on a recognised journal.PROSPERO registration number CRD42021241820. |
| first_indexed | 2024-04-11T11:09:15Z |
| format | Article |
| id | doaj.art-1384b49dc22248e0ac56ab86ad3a9cdf |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-11T11:09:15Z |
| publishDate | 2022-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-1384b49dc22248e0ac56ab86ad3a9cdf2022-12-22T04:27:57ZengBMJ Publishing GroupBMJ Open2044-60552022-08-0112810.1136/bmjopen-2021-057746Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non-haematological patients: protocol for a systematic review and meta-analysisWei Xiao0Long-yi Du1Bing Mao2Ti-wei Miao3Juan-juan Fu4Yu Li5Meilu Liu6Guilan Cheng7Chan Xiong8Department of Hematological Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan University West China Hospital, Chengdu, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan University West China Hospital, Chengdu, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan University West China Hospital, Chengdu, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan University West China Hospital, Chengdu, China1 Reproductive center, Department of Obestetrics and Gynecology, Sun Yat-Sen University, Sun Yat-Sen Memorial Hospital, Guangzhou, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan University West China Hospital, Chengdu, Sichuan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan University West China Hospital/ West China School of Nursing, Chengdu, Sichuan, ChinaRespiratory Department, No. 3 Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District) / Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaIntroduction Increasing numbers of patients with non-haematological diseases are infected with invasive pulmonary aspergillosis (IPA), with a high mortality reported which is mainly due to delayed diagnosis. The diagnostic capability of mycological tests for IPA including galactomannan test, (1,3)-β-D-glucan test, lateral flow assay, lateral flow device and PCR for the non-haematological patients remains unknown. This protocol aims to conduct a systematic review and meta-analysis of the diagnostic performance of mycological tests to facilitate the early diagnosis and treatments of IPA in non-haematological diseases.Methods and analysis Database including PubMed, CENTRAL and EMBASE will be searched from 2002 until the publication of results. Cohort or cross-sectional studies that assessing the diagnostic capability of mycological tests for IPA in patients with non-haematological diseases will be included. The true-positive, false-positive, true-negative and false-negative of each test will be extracted and pooled in bivariate random-effects model, by which the sensitivity and specificity will be calculated with 95% CI. The second outcomes will include positive (negative) likelihood ratio, area under the receiver operating characteristic curve and diagnostic OR will also be computed in the bivariate model. When applicable, subgroup analysis will be performed with several prespecified covariates to explore potential sources of heterogeneity. Factors that may impact the diagnostic effects of mycological tests will be examined by sensitivity analysis. The risk of bias will be appraised by the Quality Assessment tool for Diagnostic Accuracy Studies (QUADAS-2).Ethics and dissemination This protocol is not involved with ethics approval, and the results will be peer-reviewed and disseminated on a recognised journal.PROSPERO registration number CRD42021241820.https://bmjopen.bmj.com/content/12/8/e057746.full |
| spellingShingle | Wei Xiao Long-yi Du Bing Mao Ti-wei Miao Juan-juan Fu Yu Li Meilu Liu Guilan Cheng Chan Xiong Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non-haematological patients: protocol for a systematic review and meta-analysis BMJ Open |
| title | Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non-haematological patients: protocol for a systematic review and meta-analysis |
| title_full | Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non-haematological patients: protocol for a systematic review and meta-analysis |
| title_fullStr | Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non-haematological patients: protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non-haematological patients: protocol for a systematic review and meta-analysis |
| title_short | Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non-haematological patients: protocol for a systematic review and meta-analysis |
| title_sort | diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non haematological patients protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/12/8/e057746.full |
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