Patient Derived Xenografts for Genome-Driven Therapy of Osteosarcoma

Patient Derived Xenografts for Genome-Driven Therapy of Osteosarcoma

Osteosarcoma (OS) is a rare malignant primary tumor of mesenchymal origin affecting bone. It is characterized by a complex genotype, mainly due to the high frequency of chromothripsis, which leads to multiple somatic copy number alterations and structural rearrangements. Any effort to design genome-...

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Bibliographic Details
Main Authors: Lorena Landuzzi, Maria Cristina Manara, Pier-Luigi Lollini, Katia Scotlandi
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
osteosarcoma
patient-derived xenograft (PDX)
PDX-derived cell lines
mouse PDX clinical trial
genome-driven therapy
personalized therapy.
Online Access:https://www.mdpi.com/2073-4409/10/2/416

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