Lipofection of Single Guide RNA Targeting <i>MMP8</i> Decreases Proliferation and Migration in Lung Adenocarcinoma Cells

Lipofection of Single Guide RNA Targeting <i>MMP8</i> Decreases Proliferation and Migration in Lung Adenocarcinoma Cells

<i>Background and Objectives</i>: Matrix metalloproteinases (MMP) have been implicated as major determinants of tumour growth and metastasis, which are considered two of the main hallmarks of cancer. The interaction of <i>MMP8</i> and other signalling molecules within and adj...

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Bibliographic Details
Main Authors: Oscar David Hernandez Maradiaga, Pooi Ling Mok, Gothai Sivapragasam, Antony V. Samrot, Mohammed Safwan Ali Khan, Aisha Farhana, Badr Alzahrani, Jiabei Tong, Thilakavathy Karuppiah, Narcisse M. S. Joseph, Suresh Kumar Subbiah
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Medicina
Subjects:
CRISPR-Cas9
single guide RNA
lipofection
lung cancer
epithelial to mesenchymal transition (EMT)
matrix metalloproteinase 8 (<i>MMP8</i>)
Online Access:https://www.mdpi.com/1648-9144/57/7/710

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