Topical Application of Wogonin Provides a Novel Treatment of Knee Osteoarthritis

Topical Application of Wogonin Provides a Novel Treatment of Knee Osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant Scutellaria baicalensis (colloquially known as skullcap), has previously been shown to have direct anti-inflammatory...

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Bibliographic Details
Main Authors: Jacob F. Smith, Evan G. Starr, Michael A. Goodman, Romney B. Hanson, Trent A. Palmer, Jonathan B. Woolstenhulme, Jeffery A. Weyand, Andrew D. Marchant, Shawen L. Bueckers, Tanner K. Nelson, Matthew T. Sterling, Brandon J. Rose, James P. Porter, Dennis L. Eggett, David L. Kooyman
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Physiology
Subjects:
osteoarthritis
wogonin
inflammation
NF-κB
TGF-β1
HTRA1
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00080/full

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