A Multi-Pump Magnetohydrodynamics Lab-On-A-Chip Device for Automated Flow Control and Analyte Delivery
This article shows the development of a computer-controlled lab-on-a-chip device with three magnetohydrodynamic (MHD) pumps and a pneumatic valve. The chip was made of a stack of layers of polymethylmethacrylate (PMMA), cut using a laser engraver and thermally bonded. The MHD pumps were built using...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/20/17/4909 |
| _version_ | 1827707214086799360 |
|---|---|
| author | Rafael M. Cardoso Robson O. dos Santos Rodrigo A. A. Munoz Carlos D. Garcia Lucas Blanes |
| author_facet | Rafael M. Cardoso Robson O. dos Santos Rodrigo A. A. Munoz Carlos D. Garcia Lucas Blanes |
| author_sort | Rafael M. Cardoso |
| collection | DOAJ |
| description | This article shows the development of a computer-controlled lab-on-a-chip device with three magnetohydrodynamic (MHD) pumps and a pneumatic valve. The chip was made of a stack of layers of polymethylmethacrylate (PMMA), cut using a laser engraver and thermally bonded. The MHD pumps were built using permanent magnets (neodymium) and platinum electrodes, all of them controlled by an Arduino board and a set of relays. The implemented pumps were able to drive solutions in the open channels with a flow rate that increased proportionally with the channel width and applied voltage. To address the characteristic low pressures generated by this kind of pump, all channels were interconnected. Because the electrodes were immersed in the electrolyte, causing electrolysis and pH variations, the composition and ionic strength of the electrolyte solution were controlled. Additionally, side structures for releasing bubbles were integrated. With this multi-pump and valve solution, the device was used to demonstrate the possibility of performing an injection sequence in a system that resembles a traditional flow injection analysis system. Ultimately, the results demonstrate the possibility of performing injection sequences using an array of MHD pumps that can perform fluid handling in the 0–5 µL s<sup>−1</sup> range. |
| first_indexed | 2024-03-10T16:41:28Z |
| format | Article |
| id | doaj.art-138d578b8f4e4c2c8a6a185b66324b7d |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T16:41:28Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-138d578b8f4e4c2c8a6a185b66324b7d2023-11-20T11:56:29ZengMDPI AGSensors1424-82202020-08-012017490910.3390/s20174909A Multi-Pump Magnetohydrodynamics Lab-On-A-Chip Device for Automated Flow Control and Analyte DeliveryRafael M. Cardoso0Robson O. dos Santos1Rodrigo A. A. Munoz2Carlos D. Garcia3Lucas Blanes4Institute of Chemistry, Federal University of Uberlândia, Uberlândia 38400-000, BrazilLaboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba 81350-010, BrazilInstitute of Chemistry, Federal University of Uberlândia, Uberlândia 38400-000, BrazilDepartment of Chemistry, Clemson University, Clemson, SC 29634, USALaboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba 81350-010, BrazilThis article shows the development of a computer-controlled lab-on-a-chip device with three magnetohydrodynamic (MHD) pumps and a pneumatic valve. The chip was made of a stack of layers of polymethylmethacrylate (PMMA), cut using a laser engraver and thermally bonded. The MHD pumps were built using permanent magnets (neodymium) and platinum electrodes, all of them controlled by an Arduino board and a set of relays. The implemented pumps were able to drive solutions in the open channels with a flow rate that increased proportionally with the channel width and applied voltage. To address the characteristic low pressures generated by this kind of pump, all channels were interconnected. Because the electrodes were immersed in the electrolyte, causing electrolysis and pH variations, the composition and ionic strength of the electrolyte solution were controlled. Additionally, side structures for releasing bubbles were integrated. With this multi-pump and valve solution, the device was used to demonstrate the possibility of performing an injection sequence in a system that resembles a traditional flow injection analysis system. Ultimately, the results demonstrate the possibility of performing injection sequences using an array of MHD pumps that can perform fluid handling in the 0–5 µL s<sup>−1</sup> range.https://www.mdpi.com/1424-8220/20/17/4909MHDflow analysis systemmagnetohydrodynamicslab-on-a-chip |
| spellingShingle | Rafael M. Cardoso Robson O. dos Santos Rodrigo A. A. Munoz Carlos D. Garcia Lucas Blanes A Multi-Pump Magnetohydrodynamics Lab-On-A-Chip Device for Automated Flow Control and Analyte Delivery Sensors MHD flow analysis system magnetohydrodynamics lab-on-a-chip |
| title | A Multi-Pump Magnetohydrodynamics Lab-On-A-Chip Device for Automated Flow Control and Analyte Delivery |
| title_full | A Multi-Pump Magnetohydrodynamics Lab-On-A-Chip Device for Automated Flow Control and Analyte Delivery |
| title_fullStr | A Multi-Pump Magnetohydrodynamics Lab-On-A-Chip Device for Automated Flow Control and Analyte Delivery |
| title_full_unstemmed | A Multi-Pump Magnetohydrodynamics Lab-On-A-Chip Device for Automated Flow Control and Analyte Delivery |
| title_short | A Multi-Pump Magnetohydrodynamics Lab-On-A-Chip Device for Automated Flow Control and Analyte Delivery |
| title_sort | multi pump magnetohydrodynamics lab on a chip device for automated flow control and analyte delivery |
| topic | MHD flow analysis system magnetohydrodynamics lab-on-a-chip |
| url | https://www.mdpi.com/1424-8220/20/17/4909 |
| work_keys_str_mv | AT rafaelmcardoso amultipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT robsonodossantos amultipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT rodrigoaamunoz amultipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT carlosdgarcia amultipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT lucasblanes amultipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT rafaelmcardoso multipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT robsonodossantos multipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT rodrigoaamunoz multipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT carlosdgarcia multipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery AT lucasblanes multipumpmagnetohydrodynamicslabonachipdeviceforautomatedflowcontrolandanalytedelivery |